Results 231 to 240 of about 39,068 (264)

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

open access: yesAdvanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam   +5 more
wiley   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

open access: yesAdvanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim   +12 more
wiley   +1 more source

Ocean driven retreat of the Northeast Greenland Ice Stream following the Last Glacial Maximum. [PDF]

open access: yesNat Commun
Callard SL   +6 more
europepmc   +1 more source

Neogene plant macrofossils from West Antarctica reveal persistence of Nothofagaceae forests into the early Miocene. [PDF]

open access: yesCommun Earth Environ
Bastias-Silva J   +14 more
europepmc   +1 more source

Postglacial Echoes: Parasite Genomics Uncover Environmental Changes in Postglacial European Lakes. [PDF]

open access: yesMol Ecol
Llaberia-Robledillo M   +7 more
europepmc   +1 more source

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