Results 281 to 290 of about 5,595,222 (385)

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

The response of atmospheric nitrous oxide to climate variations during the last glacial period

, 2013
A. Schilt, M. Baumgartner, O. Eicher, J. Chappellaz, J. Schwander, H. Fischer, T. Stocker   +6 more
semanticscholar   +1 more source

Tapered Pillar Design for High‐Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells

Advanced Healthcare Materials, EarlyView.
Engineered heart tissues (EHTs) are a valuable approach in capturing human cardiac physiology and drug responses in vitro. Here, a novel tapered pillar design is developed in an EHT platform to confine tissues in a predefined position‐ at the middle of the pillar height.
Milica Dostanić, Maury Wiendels, Laura M. Windt, Mervyn P.H. Mol, Francijna E. van den Hil, Richard P. Davis, Valeria Orlova, Berend J. van Meer, Massimo Mastrangeli, Christine L. Mummery   +9 more
wiley   +1 more source

Pyrenees as the southernmost European refugium of glacial relict land snails. [PDF]

Sci Rep
Horsák M, Jiménez-Alfaro B, Pladevall-Izard E, Pérez-Haase A, Kafimola S, Horsáková V.   +5 more
europepmc   +1 more source

Using High‐Throughput Screening to Identify Crosslinking Peptides That Control Cell‐Mediated Matrix Degradation

Advanced Healthcare Materials, EarlyView.
Protease‐degradable hydrogels mimic dynamic cell‐matrix interactions, but controlling hydrogel degradation is a challenge. We screen libraries of peptides to identify sequences that are primarily degraded by membrane‐localized proteases. Crosslinking hydrogels with these peptides enables cell to spread and migrate while reducing matrix degradation ...
Yingjie Wu, Samuel J. Rozans, Abolfazl Salehi Moghaddam, E. Thomas Pashuck   +3 more
wiley   +1 more source

790,000 years of millennial-scale Cape Horn Current variability and interhemispheric linkages. [PDF]

Nat Commun
Rigalleau V, Lamy F, Ruggieri N, Sadatzki H, Arz HW, Barker S, Lembke-Jene L, Wegwerth A, Knorr G, Venancio IM, Pinho TML, Tiedemann R, Winckler G.   +12 more
europepmc   +1 more source

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

Advanced Healthcare Materials, EarlyView.
This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu, Shuai Zhou, Tingting Zou, Guangzhao Hou, Qian Xiao, Lin Li, Jianjun Yang, Wei Chen, Yingze Zhang, Hongzhi Lv   +9 more
wiley   +1 more source

Interplay between antipredator behavior, parasitism, and gut microbiome in wild stickleback populations. [PDF]

NPJ Biofilms Microbiomes
Varg JE, Brealey JC, Benhaïm D, Losada-Germain R, Boughman JW.   +4 more
europepmc   +1 more source

Functionalized Reduced Graphene Oxide‐Based Nanocomposite Hydrogels for Enhanced Osteogenesis in Bone Tissue Engineering

Advanced Healthcare Materials, EarlyView.
Charge‐opposed reduced graphene oxide fillers are co‐integrated into biopolymeric nanocomposite scaffolds, synergistically enhance osteogenesis. Multiscale characterization reveals how surface chemistry and porosity dictate ectopic mineral architecture.
George Mihail Vlăsceanu, Cătălina Ionela Zamfir, Cornel Baltă, Hildegard Herman, Alina Ciceu, Maria Alexandra Duma, Mariana Ioniță, Roxana‐Cristina Popescu, Anca Hermenean   +8 more
wiley   +1 more source

Repeated occurrences of marine anoxia under high atmospheric O₂ and icehouse conditions. [PDF]

Proc Natl Acad Sci U S A
Chen J, Li S, Zhang S, Isson T, Dahl TW, Planavsky NJ, Zhang F, Wang XD, Shen SZ, Montañez IP.   +9 more
europepmc   +1 more source