Results 321 to 330 of about 5,635,835 (408)

Unraveling the Evolutionary Tales of <i>Yunnanopilia longistaminea</i> (Opiliaceae): Insights from Genetic Diversity, Climate Adaptation, and Conservation Strategies. [PDF]

Plants (Basel)
Yang G, Yang L, Shen S, Wang Y, Wang Y.
europepmc   +1 more source

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Advanced Science, EarlyView.
Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma   +12 more
wiley   +1 more source

Sea level since the Last Glacial Maximum from the Atlantic coast of Africa. [PDF]

Nat Commun
Vacchi M, Shaw TA, Anthony EJ, Spada G, Melini D, Li T, Cahill N, Horton BP.   +7 more
europepmc   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

Advanced Science, EarlyView.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung, Chang Sik Yu, In Ho Song, Jin‐Hyung Shim, Seung‐Jae Myung, Hyun‐Wook Kang, Tae‐Eun Park   +15 more
wiley   +1 more source

Orbital and suborbital temperature variability in the central Mediterranean across the Pliocene/Pleistocene transition. [PDF]

PLoS One
Zanola E, Rodrigues T, Bonomo S, Ferretti P, Fornaciari E, Di Stefano A, Incarbona A, Preto N, Raffi I, Capraro L.   +9 more
europepmc   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Northern Hemisphere sea ice variability in a transient CGCM simulation of the past 2.6 Ma. [PDF]

Nat Commun
Mandal G, An SI, Park JH, Yun KS, Liu C, Paik S.   +5 more
europepmc   +1 more source

Fossil Floras and Glacial Periods [PDF]

Nature, 1877
openaire   +2 more sources

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Spatiotemporal glacier retreat on the Tibetan Plateau since the LGM_G to early holocene based on compilation of moraine boulder ages. [PDF]

Sci Rep
Zheng C, Zhang Z, Kong X, Granger D, Zhao Z, Zhang Z.   +5 more
europepmc   +1 more source