Results 151 to 160 of about 232,018 (415)

Marine Ice Sheet Collapse Potentially Under Way for the Thwaites Glacier Basin, West Antarctica

Science, 2014
Antarctic Collapse The West Antarctic Ice Sheet (WAIS) is particularly vulnerable to ocean warming-induced collapse. The Thwaites Glacier of West Antarctica is one of the largest WAIS regional contributors to sea level rise, and has been considered to be
I. Joughin, Ben E. Smith, B. Medley
semanticscholar   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

Angewandte Chemie, EarlyView.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano, Rosa Márquez García, Wiktor Szymanski   +2 more
wiley   +2 more sources

A Reconciled Estimate of Glacier Contributions to Sea Level Rise: 2003 to 2009

Science, 2013
Melting Away We assume the Greenland and Antarctica ice sheets are the main drivers of global sea-level rise, but how large is the contribution from other sources of glacial ice? Gardner et al. (p.
A. Gardner, G. Moholdt, J. Cogley, B. Wouters, A. Arendt, J. Wahr, E. Berthier, R. Hock, W. Pfeffer, G. Kaser, S. Ligtenberg, T. Bolch, M. Sharp, J. Hagen, M. R. van den Broeke, F. Paul   +15 more
semanticscholar   +1 more source

Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis

Advanced Science, EarlyView.
Hyaluronic acid Microneedles (MNs) are loaded with Sparfloxacin (SP) and zinc‐manganese sulfide (ZMS) for the postoperative in situ treatment of triple‐negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. These microneedles enhance antitumor immunity by activating the cGAS‐STING pathway, suppress tumor growth, reduce ...
Zhaoyou Chu, Wang Zheng, Wanyue Fu, Jun Liang, Wanni Wang, Lingling Xu, Xiaohua Jiang, Zhengbao Zha, Haisheng Qian   +8 more
wiley   +1 more source

Identifying Key Properties That Drive Redox Mediator Activity in Lactiplantibacillus Plantarum

Angewandte Chemie, EarlyView.
Synthesis and isolation of structurally diverse quinones led to defining key physicochemical properties and biochemical interactions that drive type‐II NADH dehydrogenase (Ndh2)‐dependent extracellular electron transfer activity in Lactiplantibacillus plantarum.
Benjamin T. Blackburn, Robyn A. C. Alba, Vladimir O. Porokhin, Rong Cai, Arden Hatch, Soha Hassoun, Caroline M. Ajo‐Franklin, Emily Mevers   +7 more
wiley   +2 more sources

A consistent glacier inventory for Karakoram and Pamir derived from Landsat data: distribution of debris cover and mapping challenges

Earth System Science Data, 2018
. Knowledge about the coverage and characteristics of glaciers in High Mountain Asia (HMA) is still incomplete and heterogeneous. However, several applications, such as modelling of past or future glacier development, run-off, or glacier volume, rely on ...
N. Mölg, T. Bolch, Philipp Rastner, T. Strozzi, F. Paul   +4 more
semanticscholar   +1 more source

Surface‐Engineered Cenospheres Encapsulating Phase Change Materials for Functional Cementitious Composites

Advanced Science, EarlyView.
The global energy demand drives the need for advanced energy‐efficient building solutions. While current polymeric‐shell microencapsulated PCMs show promise for thermal energy storage, their use in cementitious materials is challenged by poor shell strength and interfacial bonding. This study develops novel cement‐compatible microencapsulated PCM using
Sahand Rahemipoor, Carsten Kuenzel, Toms Valdemārs Eiduks, Andrei Shishkin, Mohammadreza Izadifar, Neven Ukrainczyk, Eduardus Koenders, Navid Ranjbar   +7 more
wiley   +1 more source

Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1

Advanced Science, EarlyView.
Through elaborate design, a biodegradable scaffold with excellent mechanical properties and suitability is fabricated, providing spatial support for subsequent physiological activities. The prepared GA‐HBC‐LIC hydrogel possesses sequential antibacterial, antioxidant, anti‐inflammatory and immunomodulatory functions, offering a suitable chemical and ...
Jiafei Chen, Xiaoxu Guan, Lina Chen, Bingzhu Zheng, Feiyu Li, Chao Fang, Yike Fu, Xiang Li, Huiming Wang, Yi Zhou   +9 more
wiley   +1 more source

Bionic Visual‐Auditory Perceptual System Based on Ionotronic Neuromorphic Transistor for Information Encryption and Decryption with Sound Recognition Functions

Advanced Electronic Materials, EarlyView.
A bionic visual‐auditory perceptual system is proposed. The system exhibits remarkable multi‐modal sensory abilities to sound and light, enabling diverse functions including encrypted sound information transmission and information decoding. The perceptual system can also perform sound recognition, resulting in the implementation of a sound lock ...
Wei Sheng Wang, Xin Li Chen, You Jie Huang, Xin Huang, Li Qiang Zhu   +4 more
wiley   +1 more source