Results 171 to 180 of about 267,963 (391)

A novel carcinogenic mouse model by site‐directed insertion of tandem human HRAS large DNA fragment into 15E1 site

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The NF‐hHRAS mouse model was generated through Chr15 E1 locus‐targeted integration of a 21 kb multicopy HRAS gene cluster. The NF‐hHRAS model demostrated tissue‐specific expression of human HRAS across multiple organs and low spontaneous tumorigenesis.
Susu Liu   +12 more
wiley   +1 more source

Summer Residency of Pacific Halibut in Glacier Bay National Park [PDF]

open access: yes, 2014
Glacier Bay National Park (Fig.1), as a Marine Protected Area (MPA), is phasing out commercial fishing of Pacific halibut (Hippoglossus stenolepis) within the park.
Evans, Mark   +2 more
core  

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

open access: yesAdvanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han   +4 more
wiley   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar   +4 more
wiley   +1 more source

Global glacier mass changes and their contributions to sea-level rise from 1961 to 2016

open access: yesNature, 2019
M. Zemp   +17 more
semanticscholar   +1 more source

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