Results 241 to 250 of about 142,920 (284)

Identification of Active Compounds of Centipeda minima for Potentiating Tumor Immunotherapy in Non‐Small Cell Lung Cancer via FANCD2‐cGAS/STING/IFN‐I Signaling Axis

open access: yesPhytotherapy Research, EarlyView.
Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang   +9 more
wiley   +1 more source

Purpurin Alleviates Chemotherapy‐Induced Thrombocytopenia Through Estrogen Receptor α Dependent Phosphoinositide 3‐Kinase/Protein Kinase B Signalling

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the in vitro and in vivo evaluation of purpurin in promoting MK maturation and platelet production, through ESR1/PI3K/AKT. ABSTRACT Chemotherapy‐induced thrombocytopenia (CIT) increases bleeding risk and compromises chemotherapy delivery.
Xiaolin Gan   +12 more
wiley   +1 more source

Synoptic and large‐scale drivers of extreme precipitation events in the Himalayas

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Months associated with maximum frequency of extreme precipitation events (EPEs). 6102 extreme precipitation days (i.e., exceeding 99th percentile for daily precipitation) occurred across the Karakoram, Western Himalayas (WH), Central Himalayas (CH) and Eastern Himalayas (EH) during 1979 to 2023.
Priya Bharati   +2 more
wiley   +1 more source

Characteristics of a <i>Dinophysis</i> cf <i>acuminata</i> Population from a Tidewater Glacier Lagoon in a Temperate Latitude: Applications to <i>Dinophysis</i> Studies. [PDF]

open access: yesMar Drugs
Díaz PA   +10 more
europepmc   +1 more source

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

open access: yesRapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler   +7 more
wiley   +1 more source

A 30 m vegetation map for the source regions of the Yangtze and Yellow Rivers from 2020-2025 ground surveys. [PDF]

open access: yesSci Data
Zou D   +10 more
europepmc   +1 more source

Forensic Hydraulic Analysis of Floodplain Connectivity Driven by Historical Beaver Dams in Colorado Headwater Streams

open access: yesRiver Research and Applications, EarlyView.
ABSTRACT As ecosystem engineers, beavers (Castor canadensis) modify river corridor form through dam building. When beavers are removed from a river corridor, their unmaintained dams wash out, altering the stream's hydrologic regime. The assumption that beaver dams increase floodplain connectivity is frequently presumed but has not been directly ...
Kayla Schultz   +4 more
wiley   +1 more source

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