Results 41 to 50 of about 4,844 (218)

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Surface Ice Velocity near the Terminus of Grey Glacier in the Southern Patagonian Icefield, Based on Direct Field Measurements

Geosciences
Glacier mass balance and ice flow dynamics, strongly influenced by climatic variability, topography, and geological–structural controls, can be precisely characterized through in situ GPS measurements of surface ice velocity, though such data remain ...
Roberto García-Esteban
doaj   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Recent structural evolution of Forni Glacier tongue (Ortles-Cevedale Group, Central Italian Alps)

Journal of Maps, 2017
Structural glaciology yields important details about the evolution of glacier dynamics in response to climate change. The maps provided here document the occurrence and evolution of brittle and ductile structures on the tongue of Forni Glacier, Ortles ...
Roberto Sergio Azzoni, Davide Fugazza, Marta Zennaro, Michele Zucali, Carlo D’Agata, Davide Maragno, Massimo Cernuschi, Claudio Smiraglia, Guglielmina Adele Diolaiuti   +8 more
doaj   +1 more source

Surface lowering of the debris-covered area of Kanchenjunga Glacier in the eastern Nepal Himalaya since 1975, as revealed by Hexagon KH-9 and ALOS satellite observations [PDF]

The Cryosphere, 2017
This study presents the geodetic mass balance of Kanchenjunga Glacier, one of the largest debris-covered glaciers in the easternmost Nepal Himalaya, which possesses a negative mass balance of −0.18 ± 0.17 m w.e.
D. Lamsal, D. Lamsal, K. Fujita, A. Sakai   +3 more
doaj   +1 more source

Electrodeposited Piezoelectric Chitosan Films: A New Approach Toward a Scalable and Standardized Fabrication of Sensors

Advanced Electronic Materials, EarlyView.
Electrodeposition is explored as an innovative and scalable approach to fabricate standardized and highly piezoelectric chitosan films. Chitosan deposition is driven onto gold‐coated silicon plates by an applied voltage. Films’ piezoelectricity is clearly proved and correlated to the material structural order.
Valeria D'Errico, Gaia de Marzo, Antonio Qualtieri, Massimo De Vittorio   +3 more
wiley   +1 more source

High‐elevation endemic plants predicted to lose habitat from changing climate in Washington State

American Journal of Botany, EarlyView.
Abstract Premise High‐elevation plants face unique challenges from potential climate change impacts that will likely require upslope migration into increasingly smaller suitable habitat. This situation is particularly acute for endemic species that by definition occupy small geographic ranges.
Nicholas L. Gjording, Erik W. Ertsgaard, David E. Giblin, Iris H. Dimpsey, Owen B. Bard   +4 more
wiley   +1 more source

Freedom dreaming of migrant justice: Critical reflections on counterspaces and institutional violence in the university

American Journal of Community Psychology, EarlyView.
Abstract US universities are built on stolen land and sustained through hierarchies of power that produce what migrant justice scholars name as b/order regimes. As institutions that claim to be sites of learning and inclusion, universities are fraught with contradictions as simultaneously sites of dispossession, exclusion, and control.
Sara L. Buckingham, Jesica Siham Fernández   +1 more
wiley   +1 more source