Results 51 to 60 of about 2,117 (263)

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Vanishing of very small glacierets throughout the Northern and Central Andes of Chile

Annals of Glaciology
Small glaciers (less than 0.5 km 2 ${ \lt }0.5\,\mathrm{km}^2$
Felipe Ugalde, Ashley Apey, Diego Pinto, Javiera Carrasco, Helena Valenzuela-Astudillo, Martina Toledo, Fernanda Manríquez, Lucas Ruiz, Cedomir Marangunic   +8 more
doaj   +1 more source

Simulation of the dynamics of the Hansbreen tidal glacier (Svalbard) based on the stochastic model

Лëд и снег, 2019
The dynamics of the Hansbreen tidal glacier (Svalbard) is manifested at different time scales. In addition to the long-term trend, there are noticeable inter-annual fluctuations. And the last ones are precisely the subject of this work.
A. V. Kislov, A. F. Glazovsky
doaj   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Identifying and mapping very small (<0.5 km2) mountain glaciers on coarse to high-resolution imagery

Journal of Glaciology, 2019
Small mountain glaciers are an important part of the cryosphere and tend to respond rapidly to climate warming. Historically, mapping very small glaciers (generally considered to be
J. R. Leigh, C. R. Stokes, R. J. Carr, I. S. Evans, L. M. Andreassen, D. J. A. Evans   +5 more
doaj   +1 more source

Glacier fluctuations and climates in the Himalayas.

Journal of Geography (Chigaku Zasshi), 1989
Glacier fluctuations during the Holocene in the Himalayas are compared with those in the world. Characteristics of glacier mass balance in the Nepal Himalaya, which belongs to the summer-accumulation type, are described. And the glacier fluctuations after the Little Ice Age in the Nepal Himalaya are discussed on the basis of variation of summer air ...
openaire   +2 more sources

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Ensemble statistics of a geometric glacier length model

Annals of Glaciology, 2017
A third-order linear glacier length model is used to analyze if the retreat of Hintereisferner in the Austrian Alps over the past 160 years is exceptional, or lies within the range of the natural variability inherent to a stationary climate.
Florian Herla, Gerard H. Roe, Ben Marzeion   +2 more
doaj   +1 more source