Results 181 to 190 of about 1,232,545 (297)

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal   +2 more
wiley   +1 more source

Earthquake-triggered cascading hazards under Arctic amplification. [PDF]

open access: yesProc Natl Acad Sci U S A
de Melo GWS   +11 more
europepmc   +1 more source

Stripping‐based approach for the recovery of volatile fatty acids from anaerobic digestion digestate: preliminary experimental investigations and modelling

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Volatile fatty acids (VFAs) are widely used across industries: as intermediates in chemical production (e.g., solvents and polymers), in pharmaceuticals and cosmetics, and as preservatives and health‐promoting additives in food and animal feed. Emerging applications also include bioplastics, bioenergy, and biotechnology.
Simeone Chianese   +6 more
wiley   +1 more source

Influence of Habitat Use on Prey Capture Behavior and Kinematics in the Pyrenean Brook Newt (Calotriton asper)

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Caves are extreme environments that impose stringent selective pressures on organisms. Consequently, many cave dwellers show extreme adaptations such as the loss of eyes, depigmentation, and a low resting metabolic rate. Yet, how the initial stages of adaptation to these extreme environments take place remains poorly understood.
Noah Heier   +4 more
wiley   +1 more source

Station‐Based Assessment of Sub‐Seasonal Climate Trends in the Tyrolean Alps (Austria)

open access: yesInternational Journal of Climatology, EarlyView.
In this study, we quantify the magnitude and significance of sub‐seasonal trends in the Tyrolean Alps (Austria) by collecting, processing and analysing meteorological observations from a dense network of climate stations. Our analysis indicates a warming rate of 0.43°C/dec over 1964–2023, greater sub‐seasonal trend variability when the analysis window ...
Erwin Rottler   +6 more
wiley   +1 more source

Heat, Health and Holidays: Reported Heat Related Adjustments to Australian Tourist Behaviour

open access: yesInternational Journal of Climatology, EarlyView.
This study assessed how climate‐related hazards affect Australian tourists' travel planning. While 80% of tourists report no impact, the 20% who do experience disruption most commonly change their activities, timing, or destination, with heat and rain affecting the same proportion of tourists across beach, city, nature, and family tourism types ...
Kerstin K. Zander   +7 more
wiley   +1 more source

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