Results 71 to 80 of about 4,434 (254)

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Vertical profile reconstruction with Pol-InSAR data of a subpolar glacier

, 2007
The last decade has seen an increasing demand for accurate mapping and wide-coverage monitoring of glaciers and ice sheets in order to measure and predict their response to global climate change and their contribution to sea level rise.
Konstantinos P. Papathanassiou, Sharma, Jayanti, Hajnsek, Irena, Papathanassiou, Konstantinos, Jayanti J. Sharma, Irena Hajnsek   +5 more
core   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Glacier mapping and monitoring using multispectral data

, 2014
Multispectral satellite data represent the primary data source for spaceborne glacier mapping and monitoring, and remote-sensing studies have generated significant results regarding global glacier observations and understandings.
Kääb, Andreas, Kargel, Jeffrey S, Casey, Kimberly, Raup, Bruce H., Casey, Kimberly A, Tobias Bolch, Raup, Bruce H, Kargel, Jeffrey S., Heid, Torborg, Leonard, Gregory J, Leonard, Gregory J., Kimberly Casey, Torborg Heid, Bruce H. Raup, Bolch, Tobias, Paul, Frank, Gregory J. Leonard, Andreas Kääb, Frank Paul, Jeffrey S. Kargel   +19 more
core   +1 more source

Mapping sediment–landform assemblages to constrain lacustrine sedimentation in a glacier-fed lake catchment in northwest Spitsbergen [PDF]

, 2015
Changes in the deposition of fine-grained rock-flour in glacier-fed lakes reflect glacier variability. This meltwater-driven signal is, however, often overprinted by other processes.
Bakke, Jostein, Jostein Bakke (831074), Willem G.M. van der Bilt (831073), Balascio, Nicholas L., Nicholas L. Balascio (831075), Bilt, Willem van der   +5 more
core   +1 more source

Chitosan‐Carbon Dot Composite Materials Form a Leaf Surface Barrier to Mitigate the Enrichment and Invasion of Nanoplastics: From Leaf Interface to Systemic Response

Advanced Science, EarlyView.
Foliar spraying of CS‐CDs can form a film on the leaves of Brassica rapa, effectively reducing the enrichment and absorption of PS in the leaves, while increasing the biomass and nutrient content of the plants. In addition, CS‐CDs can also enrich the interfoliar microbial community and activate the plant's own defense metabolic pathways.
Beibei Zhao, Mei Li, Mengjiao Fan, Chuanhuan Liu, Jie Jiang, Jia Song, Yingzhu Liu   +6 more
wiley   +1 more source

SOME FUNDAMENTAL CONSIDERATIONS ON GLACIER MAPPING

, 1966
Five glacier maps at scales of 1:5 000 and 1:10 000 were produced by the Photogrammetric Research Section of the National Research Council and the Axel Heiberg Island Expedition of McGill University for use in glaciological research in the Canadian ...
T. J. Blachut, F. Müller
core   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source