Results 41 to 50 of about 89,021 (200)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong   +13 more
wiley   +1 more source

Global detection of glacier surges from surface velocities, elevation change and SAR backscatter data between 2000 and 2024: a test of surge mechanism theories

open access: yesJournal of Glaciology
The systematic investigation of individual glacier surges across a large statistical sample is key to a better understanding of surge mechanisms. This study introduces a consistent framework for identifying glacier surges from diverse remotely sensed ...
Gregoire Guillet   +5 more
doaj   +1 more source

Glacial history and depositional environments in little Storfjorden and Hambergbukta of Arctic Svalbard since the younger dryas

open access: yesFrontiers in Earth Science, 2022
Geophysical and lithological data provide crucial information for the understanding of glacial history in Arctic Svalbard. In this study, we reconstructed the glacier-induced depositional environments of Little Storfjorden and its tributary, Hambergbukta,
Young Jin Joe   +8 more
doaj   +1 more source

Freedom dreaming of migrant justice: Critical reflections on counterspaces and institutional violence in the university

open access: yesAmerican Journal of Community Psychology, EarlyView.
Abstract US universities are built on stolen land and sustained through hierarchies of power that produce what migrant justice scholars name as b/order regimes. As institutions that claim to be sites of learning and inclusion, universities are fraught with contradictions as simultaneously sites of dispossession, exclusion, and control.
Sara L. Buckingham   +1 more
wiley   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

open access: yesThe Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Terminus advance, kinematics and mass redistribution during eight surges of Donjek Glacier, St. Elias Range, Canada, 1935 to 2016

open access: yesJournal of Glaciology, 2019
Donjek Glacier has an unusually short and regular surge cycle, with eight surges identified since 1935 from aerial photographs and satellite imagery with a ~12 year repeat interval and ~2 year active phase.
WILLIAM KOCHTITZKY   +6 more
doaj   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

open access: yesBMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning   +10 more
wiley   +1 more source

Glacier surges in Iceland, with special reference to the surges of Brúarjökull

open access: yes, 1969
The glacier surges that have occurred in Iceland since 1890 are listed, and the largest ones, those of Brúarjökull in 1890 and 1963–64, are described. The glacier area affected by the surges of Brúarjökull is about 1400 km2, the volume of ice and firn ...
Sigurdur Thorarinsson
core   +1 more source

Does Climate Risk Affect Employment Decisions? International Evidence

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the effect of climate risk on corporate employment decisions. Using a large sample from 41 countries, we find a positive association between climate risk and underinvestment in labor, notably manifesting as excessive employee layoffs.
Claude Francoeur   +3 more
wiley   +1 more source

A theory of glacier dynamics and instabilities Part 1: Topographically confined glaciers

open access: yesJournal of Glaciology, 2022
We present a theoretical framework that integrates the dynamics of glaciers with and without the topographic confinement. This Part 1 paper concerns the former, which may exhibit surge cycles when subjected to thermal switches associated with the bed ...
Hsien-Wang Ou
doaj   +1 more source

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