Results 171 to 180 of about 3,726,338 (329)

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Synergistic Effect of Silanized Ramie Fiber and Montmorillonite Clay on the Mechanical, Thermal, and Dynamic‐Mechanical Properties of Polyester Composites

Polymer Composites, EarlyView.
Multiscale composite reinforced with silane‐modified ramie fiber and clay. ABSTRACT Multiscale polymer composites combining natural fibers and layered silicates can balance stiffness, toughness, and thermal stability when interfacial interactions are properly engineered.
Daniel Rossi Klein, Maria Eduarda Escher Maletz, Matheus Vinícius Gregory Zimmermann, Ademir José Zattera, Daiane Romanzini   +4 more
wiley   +1 more source

Tidewater and lake-terminating glaciers are systematically thicker

Journal of Glaciology
Glaciers that terminate in the ocean or lakes exhibit unique dynamics that can drive rapid change. These dynamics, governed by many complex and interacting processes, challenge calibration and validation of physics-based models.
Simon Hans Edasi, Bradley Paul Lipovsky
doaj   +1 more source

Tuning adsorption and morphology in poly(glutamic acid) via controlled acidic partial deprotection

Polymer International, EarlyView.
Partial deprotection of poly(glutamic acid) generates morphologies and assemblies that match fully deprotected polypeptides in small‐molecule adsorption, extending to block copolypeptides with pH‐dependent effects. Abstract Synthetic polypeptides prepared from N‐carboxyanhydride (NCA) monomers are important platforms for environmental and medical ...
Hunter Wood, Stella Trickett, Joseph Dosch, Farin Weinger, Dan Flaherty, Stefanie Sydlik   +5 more
wiley   +1 more source

Permafrost Mass Wasting in Ice‐Rich Landscapes: Recent Advances (2013 to 2024) on Mechanisms, Dynamics and Impacts

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Across circumpolar permafrost regions, climate change is destabilizing ice‐rich hillslopes, increasing the frequency and magnitude of thaw‐driven mass wasting. This paper reviews recent studies (2013–2024) on thaw‐driven mass wasting, focusing on the processes, morphology and trajectories of geomorphic change and their implications for ...
J. M. Young, L. Farquharson, J. Luo, N. Nesterova, J. van der Sluijs, S. V. Kokelj   +5 more
wiley   +1 more source

Glacier annual balance measurement, forecasting and climate correlations, North Cascades, Washington 1984?2006

, 2008
International audienceNorth Cascade glacier annual balance measured on 10 glaciers from 1984?2006 yielded mean annual balance (ba) of ?0.54 m/a, and ?12.38 m cumulatively.
Pelto, M. S.
core   +2 more sources

Cryostratigraphy of Rhythmic Segregated Ice in Colluvium and Implications for Permafrost Slope Stability

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT The amount and stratigraphic setting of ground ice in permafrost slopes is a key control on the style and magnitude of permafrost mass wasting. Understanding the spatial and stratigraphic variations in ground ice distribution on permafrost slopes is therefore a fundamental property in assessing the stability of permafrost hillslopes.
Joseph M. Young, Alejandro Alvarez, Duane Froese   +2 more
wiley   +1 more source

Permafrost Terrain Disturbance Susceptibility in the Nacho Nyäk Tagé (Stewart River) Watershed, Yukon, Canada

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT The Nacho Nyäk Tagé (Stewart River) watershed in central Yukon (Canada) is characterized by discontinuous permafrost that is locally highly sensitive to thaw. This study aims to map the spatial distribution of permafrost terrain disturbances (PTDs) in the watershed and model thaw susceptibility to support community‐led land‐use planning by the
Frederic Brieger, Murray Richardson, Shawn Kenny   +2 more
wiley   +1 more source

Spatial Variability of Permafrost and Active Layer Thickness in a Forested Hillslope of the Taiga Shield

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Under continued climate warming, understanding present‐day permafrost distribution and the controls on ground thaw are critical for predicting permafrost thaw trajectories and associated implications. This study presents a high‐resolution investigation of permafrost extent and active layer thickness (ALT) across a coniferous forested hillslope
Alana Muenchrath, Christopher Spence, Andrew Ireson   +2 more
wiley   +1 more source

Changes in Glacier Volume in the North Bank of the Bangong Co Basin from 1968 to 2007 Based on Historical Topographic Maps, SRTM, and ASTER Stereo Images

, 2015
Junfeng Wei, Shiyin Liu, Wanqin Guo, Xu Junli, Wei-jia Bao, Shangguan Donghui   +5 more
semanticscholar   +1 more source