Results 81 to 90 of about 4,147,828 (242)

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Robust NbN‐on‐Si/SiGe Hybrid Microwave Quantum Circuits With Long‐Term Stability

Advanced Electronic Materials, EarlyView.
Superconducting NbN resonators integrated with Si/SiGe quantum wells based semiconducting chip are investigated as a CMOS–compatible platform for scalable quantum hardware. Temperature–dependent microwave spectroscopy reveals loss mechanisms from TLS, quasiparticles, and scattering.
Paniz Foshat, Samane Kalhor, Shima Poorgholam‐khanjari, Douglas Paul, Martin Weides, Kaveh Delfanazari   +5 more
wiley   +1 more source

Demographic, clinical, and social data predictive of 1-month mortality post-aneurysmal subarachnoid hemorrhage

World Neurosurgery: X
Introduction: Attempts to develop a multidimensional predictive model for outcomes after aneurysmal subarachnoid hemorrhage have largely failed. Other demographic, clinical, and social information may enhance the predictive value of clinical scales for ...
Ansley Grimes Stanfill, Xueyuan Cao, Patrick Devlin, Lucas Elijovich, Adam Arthur, Kayla M. Wynja, Drew Prescott, Brandon Baughman   +7 more
doaj   +1 more source

Etiology and Outcome of Status Epilepticus

Pediatric Neurology Briefs, 2005
The etiology and outcome of status epilepticus (SE) in 135 children (76 boys, 59 girls), ages 1 month to 15 years, admitted to Nemazee Hospital, Shiraz, Iran, between 1999 and 2004, were studied retrospectively, and outcomes were rated according to the ...
J Gordon Millichap
doaj   +1 more source

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

Oncology Letters, 2017
Systemic inflammation, as evidenced by the Glasgow prognostic score (GPS), predicts cancer-specific survival in various cancer types. The aim of this study was to evaluate the significance of the GPS in the therapeutic outcome of the patient following surgical resection for hepatocellular carcinoma.
Hiroaki, Shiba, Takashi, Horiuchi, Taro, Sakamoto, Kenei, Furukawa, Yoshihiro, Shirai, Tomonori, Iida, Yuki, Fujiwara, Koichiro, Haruki, Katsuhiko, Yanaga   +8 more
openaire   +3 more sources

Preoperative Total Iron‐Binding Capacity Is a Potential Surrogate Marker of Long‐Term Outcomes After Pancreatectomy for Pancreatic Cancer

Annals of Gastroenterological Surgery, EarlyView.
Preoperative low serum total iron‐binding capacity (TIBC) was associated with poorer overall survival and recurrence‐free survival after pancreatectomy for pancreatic cancer. These findings suggest that preoperative serum TIBC may serve as a simple surrogate marker for long‐term outcomes in patients undergoing pancreatectomy.
Taishi Yamane, Hiromitsu Hayashi, Hiroshi Sawayama, Takashi Matsumoto, Toru Takematsu, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Hirohisa Okabe, Masaaki Iwatsuki   +9 more
wiley   +1 more source

Neuropsychological, functional and behavioural outcome and predictors of outcome in a sample of traumatic brain injury litigants [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 147-162).Generally, this study aimed to explore whether financial settlement in litigation influences outcome and recovery from closed head injury in a sample of traumatic brain injured (TBI ...
Gouse, Hetta
core   +1 more source

A comparison of the diagnostic power of the Full Outline of Unresponsiveness scale and the Glasgow coma scale in the discharge outcome prediction of patients with traumatic brain injury admitted to the intensive care unit

Saudi Journal of Anaesthesia, 2014
Background and Aim : This study aimed to determine whether the Full Outline of Unresponsiveness (FOUR) score is an accurate predictorof discharge outcome in traumatic brain injury (TBI) patients and to compare its performanceto Glasgow coma scale (GCS ...
Mohammad Ali Heidari Gorji, Seyed Hosein Hoseini, Afshin Gholipur, Reza Ali Mohammadpur   +3 more
doaj   +1 more source

Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology

Annals of Neurology, EarlyView.
Objective Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.
Ganna Leonenko, Kalliopi Mavromati, Lynne Hughes, Jonas S. Sundarakumar, Keeley Brookes, Kevin Morgan, Terry Quinn, Valentina Escott‐Price, the Alzheimer's Disease Neuroimaging Initiative   +8 more
wiley   +1 more source

Engineered 3D Fibronectin‐Based Environments Modulate the Pathogenic Profile of Arthritic Synovial Fibroblasts

Advanced NanoBiomed Research, EarlyView.
Fibroblast behavior is shaped by the surrounding microenvironment, yet conventional culture systems often fail to capture disease‐relevant phenotypes. Here, platform‐dependent responses of healthy and arthritic synovial fibroblasts are examined across 2D and 3D culture systems. Distinct inflammatory and proliferative signatures emerge, highlighting how
Aneesah Khan, Piaopiao Pan, Yanling Lan, Çağlar Çi̇l, Julia Isakova, Yilin Wang, Theodora Rogkoti, Thanutchaporn Sartyoungkul, James F. C. Windmill, Jonathan William, Manuel Salmeron‐Sanchez, Margaret H. Harnett, Oana Dobre, Miguel A. Pineda   +13 more
wiley   +1 more source