Results 61 to 70 of about 216,525 (294)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Radial dependence of thermal, structural and micro deformation characteristics in Cu-Zr-Al bulk metallic glass subjected to high pressure torsion

Materials & Design
Disk of a Cu38Zr54Al8 bulk metallic glass was subjected to severe plastic deformation by high pressure torsion up to 25 revolutions. X-ray diffraction was utilized to investigate the microstructure of the deformed sample, while the thermal behavior of ...
Talaye Arjmandabasi, Ádám Révész, Viktória K. Kis, Dávid Ugi, Erhard Schafler, Zsolt Kovács   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Micro-lateral extrusion of Zr55Cu30Al10Ni5 bulk metallic glass under low-frequency vibration loading

MATEC Web of Conferences, 2015
The effect of vibration on the micro-forming ability of Zr55Cu30Al10Ni5 bulk metallic glass in its supercooled liquid region was studied. The experiment of micro-extrusion was carried out under different amplitude (38 ∼ 760 N) and different frequency (0 ...
Li Jinyang, Zheng Zhizhen, Wu Xiao, Li Jianjun   +3 more
doaj   +1 more source

A New Ni-Based Metallic Glass with High Thermal Stability and Hardness

Metals, 2015
Glass forming ability (GFA), thermal stability and microhardness of Ni51−xCuxW31.6B17.4 (x = 0, 5) metallic glasses have been investigated. For each alloy, thin sheets of samples having thickness of 20 µm and 100 µm were synthesized by piston and anvil
Aytekin Hitit, Hakan Şahin, Pelin Öztürk, Ahmet Malik Aşgın   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Glass-forming ability and magnetic properties of CoFeMoYB bulk glassy alloys with large supercooled liquid region

, 2010
Co-based bulk glassy alloys with diameters up to 4 mm were formed in Co41+ xFe28Mo4Y5-xB22 (x = 0-1.5) system. The effect of Y content on the glass-forming ability and soft-magnetic properties of the Co-based bulk glassy alloys was investigated.
Shen, Baolong, Man, Qikui, Kimura, Hisamichi, Shen, BL, Dong, Yaqiang, Sun, Huaijun, Makino, Akihoro, Inoue, Akihisa   +7 more
core   +1 more source

Molecular Dynamic Characteristic Temperatures for Predicting Metallic Glass Forming Ability

, 2021
Plots, data, and models used throughout a molecular dynamics study of characteristic temperatures to quantify glass forming ability for metallic ...
Lane Schultz (9611719), Ben2 Afflerbach (5231282), Izabela Szlufarska (10716439), Dane Morgan (796750)   +3 more
core   +1 more source

Understanding the Origin of Glass Forming Ability in Metallic Glasses [PDF]

, 2018
The glass forming ability of metallic glasses has been one of their most studied yet least understood properties. Crystal nucleation in a recently development Ni-based metallic glass was studied by undercooling in a DSC under a variety of conditions and
Hoff, Andrew Taylor
core   +1 more source

Atomic-Scale Mechanisms of the Glass-Forming Ability in Metallic Glasses

Physical Review Letters, 2012
The issue, composition dependence of glass-forming ability (GFA) in metallic glasses (MG), has been investigated by systematic experimental measurements coupled with theoretical calculations in Cu-Zr and Ni-Nb alloy systems. It is found that the atomic-level packing efficiency strongly relates to their GFA.
Yang, L., Guo, G. Q., Chen, L. Y., Huang, C. L., Ge, T., Chen, D., Liaw, P. K., Saksl, K., Ren, Y., Zeng, Q. S., LaQua, B., Chen, F. G., Jiang, J. Z.   +12 more
openaire   +4 more sources