Results 51 to 60 of about 626,760 (294)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Silver Orthophosphate Immobilized on Flaky Layered Double Hydroxides as the Visible-Light-Driven Photocatalysts

International Journal of Photoenergy, 2012
Flaky layered double hydroxide (FLDH) was prepared by the reconstruction of its oxide in alkali solution. The composites with FLDH/Ag3PO4 mass ratios at 1.6 : 1 and 3 : 1 were fabricated by the coprecipitation method.
Xianlu Cui, Yaogang Li, Qinghong Zhang, Hongzhi Wang   +3 more
doaj   +1 more source

Slow Dynamics in Glasses

, 2005
Minimalist theories of complex systems are broadly of two kinds: mean-field and axiomatic. So far all theories of complex properties absent from simple systems and intrinsic to glasses are axiomatic.
J. C. Phillips, R. A. Cheville, R. Bergman, W. Kob, Y. E. Lozovik   +4 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Study of gamma radiation shielding efficiency by 0.5TeO₂-(0.5-x)Bi₂O₃-xWO₃ glasses

Eurasian Journal of Physics and Functional Materials, 2021
This article is devoted to the study of determination of gamma radiation shielding efficiency by new radiation-resistant glasses of the 0.5TeO2-(0.5-x)Bi2O3-xWO3 type.
A. .. Temir, K. Sh. Zhumadilov, A. .. Kozlovskiy, A. .. Smagulova, D. I. Shlimas, A. V. Trukhanov   +5 more
doaj   +1 more source

Structure and dynamics of Oxide Melts and Glasses : a view from multinuclear and high temperature NMR [PDF]

, 2007
Solid State Nuclear Magnetic Resonance (NMR) experiments allow characterizing the local structure and dynamics of oxide glasses and melts. Thanks to the development of new experiments, it now becomes possible to evidence not only the details of the ...
Cormier, L., Coutures, J. P., Fayon, F., Florian, P., Hiet, J., Massiot, D., Montouillout, V., Neuville, D., Pellerin, N., Roiland, C.   +9 more
core   +6 more sources

Amethystine Glass [PDF]

Science, 1908
n ...
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Novel Eu³⁺-Doped Glasses in the MoO₃-WO₃-La₂O₃-B₂O₃ System: Preparation, Structure and Photoluminescent Properties

Molecules
Novel multicomponent glasses with nominal compositions of (50−x)MoO3:xWO3:25La2O3:25B2O3, x = 0, 10, 20, 30, 40, 50 mol% doped with 3 mol % Eu2O3 were prepared using a conventional melt-quenching method.
Lyubomir Aleksandrov, Margarita Milanova, Aneliya Yordanova, Reni Iordanova, Kenji Shinozaki, Tsuyoshi Honma, Takayuki Komatsu   +6 more
doaj   +1 more source