Results 151 to 160 of about 21,105,669 (168)

Pharmacokinetic Analysis of Glaucocalyxin A in Rat Plasma by Liquid-Liquid Extraction and HPLC

Planta Medica, 2009
A validated HPLC method is described for determination of glaucocalyxin A in rat plasma using liquid-liquid extraction and UV absorbance detection. The extraction recovery of glaucocalyxin A ranged from 81.72 % to 79.25 %, the linear range was 0.2-10 microg/mL, and R was 0.9984.
Luye, Cao, Jin, Sun, Yun, Shen Li, Zijun, Chen, Yikui, Li   +4 more
openaire   +2 more sources

Glaucocalyxin A as a natural product increases amyloid &bgr; clearance and decreases tau phosphorylation involving the mammalian target of rapamycin signaling pathway

NeuroReport, 2019
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder correlated with age, characterized by the accumulation of amyloid &bgr; (A&bgr;) plaques and neurofibrillary tangles.
Tingting Zhou, Jingjing Zhuang, Zhiwei Wang, Yaodong Zhou, Wen Li, Zhimin Wang, Zhi-yuan Zhu   +6 more
semanticscholar   +1 more source

Glaucocalyxin A and B Regulate Growth and Induce Oxidative Stress in Lettuce (Lactuca sativa L.) Roots

Journal of Plant Growth Regulation, 2013
Glaucocalyxin (Gla) A–C are major ent-kaurane diterpenoids isolated from Isodon japonicus var. glaucocalyx (Maxim.) H. W. Li. This study investigated the possible interference of these diterpenoids with root growth and its mechanism of action in lettuce (Lactuca sativa L.) seedlings.
Wen Hua Yang, Li Ping Zheng, Hui Yan Yuan, Jian Wen Wang   +3 more
openaire   +1 more source

Quantitative determination of glaucocalyxin A in rat plasma by LC-MS/MS: Application to a preclinical pharmacokinetic study

Analytical Methods, 2013
A rapid and sensitive LC-MS/MS method for the determination of glaucocalyxin A (GLA) in rat plasma using oridonin as an internal standard was developed and validated. Chromatogram separation was performed on a reversed phase C18 column, using acetonitrile: 2 mM ammonium acetate containing 0.05% formic acid (45:55, v/v) as the mobile phase.
Lili Ren, Bo Ma, Guoguang Chen, Qi Zhang, Ping Wei, Yinhui Liu, Jing Li   +6 more
openaire   +1 more source

Validation of an UHPLC-MS/MS Method for the Determination of Glaucocalyxin A, a Novel Potent Negative Akt Regulator in Rat Plasma, Lung and Brain Tissues: Application to a Pharmacokinetic Study.

Journal of Chromatographic Science, 2019
Glaucocalyxin A, a novel potent negative Akt regulator, is a major active constituent of Rabdosia japonica. A simple, specific and sensitive ultra-high pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed and ...
Zhipeng Deng, Qian Liu, Jixiang He, Sixi Zhang, W. Zhou   +4 more
semanticscholar   +1 more source

Synthesis and Antiproliferative Activity Evaluation of Novel Glaucocalyxin A-1,2,3-Triazole Derivatives

Chinese Journal of Organic Chemistry, 2022
Bai Suping, Su Mingming, Li Ting, He Jianchao, Zhou Nanqian, Hu Panpan, Li Zhangyuan, Ma Wen, Wei Haiyuan, Zhang Tao   +9 more
openaire   +1 more source

[Effect of glaucocalyxin A on level of Th1/Th2 type cytokines in mice].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007
To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those ...
Zi-jun, Chen, Yun-sen, Li, Ji-yan, Zhou, Zheng-tao, Wang   +3 more
openaire   +1 more source

Glaucocalyxin A suppresses osteoclastogenesis induced by RANKL and osteoporosis induced by ovariectomy by inhibiting the NF-κB and Akt pathways.

Journal of Ethnopharmacology, 2021
Mei-Song Zhu, Jing Shan, Huaen Xu, Guoming Xia, Qiang Xu, Kun Quan, Xuqiang Liu, Min Dai   +7 more
semanticscholar   +1 more source

Synthesis of (–)-Glaucocalyxin A

Synfacts, 2020
openaire   +1 more source

Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993
Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and
B, Zhang, K, Long
openaire   +1 more source