Results 61 to 70 of about 21,105,669 (168)

Diagnostic Efficacy of Urinary IGFBP7 and TIMP2 Levels in Early Acute Kidney Injury [PDF]

Background: Acute kidney injury (AKI) is an acute renal insufficiency syndrome, often associated with high morbidity and mortality. Currently, there is a lack of early diagnostic biomarkers.
Huang, Yuqing, Li, Fuhao, Li, Xiaoping, Liu, Jiajun, Xia, Jumei, Yao, Wencui, Zheng, Linhong, Zhu, Hongguo   +7 more
core   +2 more sources

Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells

The FEBS Journal
Thioredoxin reductase 1 (TXNRD1) has been identified as one of the promising chemotherapeutic targets in cancer cells. Therefore, a novel TXNRD1 inhibitor could accelerate chemotherapy in clinical anticancer research.
Ling Wang, Shibo Sun, Haowen Liu, Qiuyu Zhang, Yao Meng, Fan Sun, Jianjun Zhang, Haiyan Liu, Weiping Xu, Zhiwei Ye, Jie Zhang, Bingbing Sun, Jianqiang Xu   +12 more
semanticscholar   +1 more source

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity [PDF]

, 2014
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
Gabriel Olmos, Jerònia Lladó
core   +3 more sources

Lentiviral Vector-Mediated SHC3 Silencing Exacerbates Oxidative Stress Injury in Nigral Dopamine Neurons by Regulating the PI3K-AKT-FoxO Signaling Pathway in Rats with Parkinson’s Disease [PDF]

, 2018
Background/Aims: Parkinson’s disease (PD) is a prevalent disease that leads to motor and cognitive disabilities, and oxidative stress (OS) injury was found to be related to the etiology of PD.
Jian Gong, Lei Zhang, Qian Zhang, Qin-Shang Yang, Xiang Li, Xiang-Jun Xia, Yin-Yuan Liu   +6 more
core   +1 more source

Anticancer diterpenes of African natural products: Mechanistic pathways and preclinical developments [PDF]

64 p.Background: The African continent is home to five biodiversity hotspots, boasting an immense wealth of medicinal flora, fungi and marine life. Diterpenes extracted from such natural products have compelling cytotoxic activities that warrant further ...
Almeida Rosatella, Andreia de, Bangay, Gabrielle, Brauning, Florencia Z., Dias De Mendonça Rijo, Patricia, Domínguez Martín, Eva María, Díaz Lanza, Ana María, Efferth, Thomas, Ferreira Gonçalves, Bruno Miguel, Hussein Mohammed, Ahmed A.   +8 more
core   +1 more source

Preparation and Evaluation of Glaucocalyxin A SustainedRelease Pellets Based on Phospholipid Complex System with Enhanced Bioavailability

Journal of Pharmacy and Pharmacology, 2020
Objective: Glaucocalyxin A (GLA) suffers from low oral bioavailability and rapid in vivo metabolism. Therefore, the purpose of this study was to develop a new formulation to enhance the oral bioavailability simultaneously sustained release of GLA ...

semanticscholar   +1 more source

A novel strategy for the characterization of glaucocalyxin A metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on DDA and DIA data acquisitions

RSC Advances, 2020
Glaucocalyxin A (GLA) belongs to the natural ent-kauranoid diterpenoids family with antitumor, antifibrotic, anticoagulative, antioxidant, and anti-AD effects.
Wenjing Sun, Yiran Jin, Shuai Guan, Meng Yang, Miaoting Zhang, Jialin Hou, Yingfeng Du   +6 more
semanticscholar   +1 more source

Preparation, characteristic and pharmacological study on inclusion complex of sulfobutylether-β-cyclodextrin with glaucocalyxin A

Journal of Pharmacy and Pharmacology, 2014
Abstract Objectives The objective of this study was to improve the water solubility and solubility of glaucocalyxin A (GLA) by producing its inclusion complex with sulfobutylether-β-cyclodextrin (SBE-β-CD).
Lili, Ren, Jianghui, Jing, Guoguang, Chen, Yanfei, Miao, Ping, Wei   +4 more
openaire   +2 more sources

Preparation and antitumor effects of glaucocalyxin A-γ-cyclodextrin clathrate.

International journal of clinical and experimental medicine, 2015
To improve the water solubility of glaucocalyxin A (GLA) by the preparation of glaucocalyxin A γ-cyclodextrin clathrate (GLA-γ-CD) and to investigate the inhibitory effect of GLA-γ-CD on tumor growth in S180 cell xenografts.GLA-γ-CD, γ-cyclodextrin (γ-CD) and GLA were combined at a mass ratio of 1:1, dissolved in 60°C water by stirring.
Chong, Zhang, Yan, Qu, Yan-Long, Jia, Xiao-Jun, Shang, Su-Ping, Bai   +4 more
openaire   +1 more source

Pedalitina de Isodon japonica, un inactivador de la lipo oxigenasa-1 de poroto de soya [PDF]

, 2016
Pedalitin, isolated from the aerial part of Rabdosia japonica (Labiatae), inhibited soybean lipoxygenase-1 (EC 1.13.11.12, Type I) with an IC50 of 152.5 M.
Alarcon, Julio, Cespedes, Carlos L., Ha, Tae Joung, Isobe, Takahiko, Kubo, Isao, Werner, Enrique   +5 more
core   +1 more source