GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway [PDF]
BackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Hengliang Shi +5 more
core +1 more source
Recent development of mitochondrial metabolism and dysfunction in osteoarthritis [PDF]
Osteoarthritis is a degenerative joint disorder characterized by cartilage degradation, synovial inflammation, and altered subchondral bone structure.
Ahmad Alhaskawi +3 more
core +1 more source
Catalytic Asymmetric Addition and Substitution Reactions with Grignard Reagents:Do We Know It All? [PDF]
Catalysis has been a cornerstone in organic synthesis, enabling a variety of highly efficient and selective C−C bond formation reactions, in particular enantioselective addition and substitution of Grignard reagents.
Castiñeira Reis, Marta +2 more
core +1 more source
Drug Delivery, 2015 Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined ultrasonication and were characterized by dynamic light scattering (DLS), transmission electron ...
Meihua, Han +4 more
openaire +2 more sources
A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly [PDF]
, 2019 Age is associated with increased risk for several disorders including dementias, cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with cognitive decline particularly in cognitive domains associated with memory and ...
Con Stough, Masoumeh Tangestani Fard
core +1 more source
Asian Pacific Journal of Cancer Prevention, 2013 THis study was conducted to analyze the molecular mechanisms responsible for anti-proliferation effects of glaucocalyxin A in cultured MCF-7 and Hs578T breast cancer cells. The concentration that reduced cell viability to 50% (IC50) after 72 h treatment was derived and potential molecular mechanisms of anti-proliferation using the IC50 were ...
Mei, Li +3 more
openaire +3 more sources
Recent advances and future directions on GLA-producing organisms [PDF]
Gamma-linolenic acid (GLA) is a biologically active omega-6 fatty acid with anti-inflammatory, immunomodulatory, and cardiovascular protective effects. It is a vital constituent of human health and is finding more widespread applications in nutritional ...
Ingvarsson, Pär
core +4 more sources
HMGB1-dependent signaling in the regulation of mast cell activity during inflammation [PDF]
BackgroundDamaged cells release endogenous molecules known as alarmins into the extracellular space following cellular injury. Alarmins may function as adjuvants by interacting with PRRs to indicate danger and initiate a localized sterile inflammatory ...
Elżbieta Kozłowska +6 more
core +1 more source
Chrysin directing an enhanced solubility through the formation of a supramolecular cyclodextrin–calixarene drug delivery system: a potential strategy in antifibrotic diabetes therapeutics [PDF]
Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability.
Budai, István +12 more
core +2 more sources
Determination of the Anti-Oxidative Stress Mechanism of Isodon suzhouensis Leaves by Employing Bioinformatic and Novel Research Technology. [PDF]
ACS Omega, 2023 Wang W +8 more
europepmc +1 more source