Results 31 to 40 of about 39,123 (220)

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

From Flexible to Conformable Pressure Sensors: Mechanisms, Materials, and Biomedical Applications

Advanced Electronic Materials, EarlyView.
This review highlights recent progress, challenges and future opportunities in pressure sensing for advanced biomedical applications. We summarize key transduction mechanisms and emerging material strategies, discuss representative wearable and implantable applications for continuous physiological monitoring and provide a focused perspective on barrier
Rishabh B. Mishra, Andrea Ottomaniello, Virgilio Mattoli   +2 more
wiley   +1 more source

The genetics of primary open angle glaucoma [PDF]

British Journal of Ophthalmology, 1997
The advent of the discipline of molecular genetics over the past decade has led to a dramatic growth in our understanding of the genetics of a myriad of diseases. Ophthalmology has benefited greatly from this new technology, with significant advances in our knowledge about conditions as varied as aniridia and retinitis pigmentosa.1 2 Our understanding ...
A, Booth, A, Churchill, R, Anwar, M, Menage, A, Markham   +4 more
openaire   +2 more sources

Hypertension in Primary Open Angle Glaucoma

Journal of Nepal Medical Association, 2014
Introduction: The impact of vascular factors in POAG is well known and controversial. Some reports have shown high blood pressure in POAG, some low systolic blood pressure and some described no difference in blood pressure between POAG and controls ...
Suprada Pokharel, Dakki Sherpa, Om Krishna Malla   +2 more
doaj   +3 more sources

A Review of Artificial Intelligence in Ophthalmology: Key Aspects, Challenges, and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is increasingly reshaping ophthalmology because the specialty depends heavily on structured imaging, quantitative measurements, and repeatable diagnostic workflows. This review provides a clinically grounded and translationally oriented synthesis of AI in ophthalmology, covering methodological foundations ...
Partha Pratim Ray
wiley   +1 more source

A study of primary open angle glaucoma in Diabetic patients [PDF]

Perspectives In Medical Research, 2018
Introduction: Primary open angle glaucoma is the commonest form of glaucoma accounting for atleast half of all the glaucomas. Intra Ocular Pressure is a definite and important risk factor for developing glaucomatous damage. Open-angle glaucoma is an
Shri Krishna Ingle1 , Yasam Soumya2 , Jaganmohan Rao3 , S. Kapil4
doaj  

Association between hypertriglyceridemia and open angle glaucoma: A case report

Indian Journal of Ophthalmology, 2019
Hypertriglyseridemia is a metabolic disorder that can cause vascular dysfucntion and be causally associated with glaucoma. Herein we present the case of a 16-year-old boy with hypertriglyseridemia with open-angle glaucoma.
Mayuri Bakulesh Khamar, Arpita P Sthapak, D Vijayevarshcini, Priyanka M Patel   +3 more
doaj   +1 more source

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

iMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson, Liam Scott, Irene Leung, Ferenc Sallo, Catherine Egan, Tunde Peto, The MacTel Consortium, Melanie Bahlo, Martin Friedlander, Simone Tzaridis, Lea Scheppke, Roberto Bonelli   +11 more
wiley   +1 more source

Study of topical corticosteroid response in glaucoma suspects and family members of established glaucoma patients

Indian Journal of Ophthalmology, 1987
The present study was conducted to study the topical steroid response in glaucoma suspects and family members of established glaucoma patients and its hereditary pattern The cases understudy were divided into three groups, namely normal (25 cases ...
Jilani F, Khan A, Kesharwani R
doaj  

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source