Results 131 to 140 of about 344,170 (326)

Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids

open access: yesChemistryOpen, EarlyView.
Two novel carboxamide hydrazone hybrids are synthesized and characterized. Structural, spectroscopic, and computational analyses reveal dominant hydrogen bonding, π–π stacking, and reactive sites. Compound 2b exhibits potent antibacterial activity against Staphylococcus aureus, highlighting its potential as a cost‐effective therapeutic agent.
Nabila A. Kheder   +6 more
wiley   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa   +7 more
wiley   +1 more source

Lived Experience of Patients Living with Glaucoma: A Qualitative Study

open access: yesJournal of Nepal Medical Association
Introduction: Glaucoma is the leading cause of irreversible blindness in the world. There are limited qualitative study focusing on patients’ experience of glaucoma.
Anjani Kumar Singh   +4 more
doaj   +1 more source

A Comparison of Emotionally Stimulated and Conventionally Collected Tears Using Bottom‐Up, Label‐Free Quantitative Proteomic Analysis—A Pilot Study

open access: yesPROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Proteomic analysis of biofluids is central for identifying disease biomarkers. Tears have become popular targets for biomarker discovery and biosensor development, largely because they can be collected noninvasively and are rich sources of biomarkers for ocular and systemic diseases. Although basal and reflex tears have been well characterized,
Campbell Bruce Mousseau   +3 more
wiley   +1 more source

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell   +4 more
wiley   +1 more source

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