Results 141 to 150 of about 464,611 (330)

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

open access: yesAging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu   +10 more
wiley   +1 more source

Web Applicable Computer-aided Diagnosis of Glaucoma Using Deep Learning [PDF]

open access: yes, 2018
Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by different types of ...
De Neve, Wesley   +5 more
core   +1 more source

DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy

open access: yesAging Cell, EarlyView.
In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding   +8 more
wiley   +1 more source

Quantitative analysis of intraocular pressure and clinical-morphometric characteristics in Peters’ anomaly: a single-center study

open access: yesFrontiers in Medicine
PurposeTo quantitatively analyze intraocular pressure (IOP) alongside clinical and morphometric findings in a cohort of children with Peters’ anomaly (PA).MethodsThis single-center retrospective study included a series of 46 children with PA.
Sebastião Cronemberger   +7 more
doaj   +1 more source

Ythdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline

open access: yesAging Cell, EarlyView.
The m6A reader YTHDF2 regulates retinal degeneration caused by aging, which is mediated by its target mRNAs Hspa12a and Islr2. ABSTRACT Aging‐related retinal degeneration and vision loss have been severely affecting the elderly worldwide. Previously, we showed that the m6A reader YTHDF2 is a negative regulator for dendrite development and protection of
Fugui Niu   +4 more
wiley   +1 more source

“We All Live in One World”: Challenging Settler Mythologies With Sovereign Assertions

open access: yesAnthropology &Education Quarterly, EarlyView.
ABSTRACT The paper examines how settler colonial myths perpetuate systemic inequities in the education of Native students in Southern Utah. It critiques the “two‐worlds” narrative used to justify marginalization and explores how Native parents use sovereign assertions to challenge these injustices.
Cynthia Benally, Donna Deyhle, Beth King
wiley   +1 more source

Home - About - Disclaimer - Privacy