Results 171 to 180 of about 470,158 (371)

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell   +4 more
wiley   +1 more source

Quantitative analysis of intraocular pressure and clinical-morphometric characteristics in Peters’ anomaly: a single-center study

open access: yesFrontiers in Medicine
PurposeTo quantitatively analyze intraocular pressure (IOP) alongside clinical and morphometric findings in a cohort of children with Peters’ anomaly (PA).MethodsThis single-center retrospective study included a series of 46 children with PA.
Sebastião Cronemberger   +7 more
doaj   +1 more source

Impact of Mechanistic Modeling and Simulation Methodologies on Product‐Specific Guidance Development for Non‐Orally Administered Drug Products

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski   +6 more
wiley   +1 more source

Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation

open access: yesSensory Neuroscience, EarlyView.
ABSTRACT The secretome refers to the in vivo ensemble of molecular entities that are found in interstitial spaces. It is then the mere secreted products of the cells, as all biomolecules in the interstitial cellular spaces also undergo modifications. The fractionated secretome may hold potential as a cell‐free therapy option due to its role in tissue ...
Maria D. Cabrera   +3 more
wiley   +1 more source

An Interpretable Artificial Intelligence System for Crohn's Disease Ulcer Identification and Grading on Double‐Balloon Enteroscopy Images

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Background Crohn's disease (CD) is an incurable inflammatory bowel disease that can lead to a variety of complications and requires lifelong treatment. However, the diagnosis and management of Crohn's disease exhibit high rates of misdiagnosis and missed diagnoses, along with significant variability, among primary care facilities and novice ...
Qiuyuan Liu   +16 more
wiley   +1 more source

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