Results 291 to 300 of about 426,287 (394)

Evaluating the impact of general practice pharmacist‐led person‐centred medicines reviews on medicines appropriateness and patient‐reported outcome measures

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to investigate the impact of pharmacist‐led person‐centred medicines reviews in general practices on medicines appropriateness, polypharmacy indicators (high‐risk prescribing markers), and patient‐reported outcome measures (PROMs).
Clare Kinahan   +9 more
wiley   +1 more source

Progress on the development of Class A GPCR‐biased ligands

open access: yesBritish Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales   +20 more
wiley   +1 more source

Dupilumab‐Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry

open access: yesClinical &Experimental Allergy, EarlyView.
DAOSD occurred in 34.6% of dupilumab‐treated paediatric AD patients, of which 30.6% required ocular anti‐inflammatory therapy. This high incidence rate underscores the importance of awareness during dupilumab treatment in paediatric patients. Elevated baseline serum IgE levels (≥ 3000 kU/L) may predict DAOSD development in paediatric AD patients ...
Lisa P. van der Rijst   +6 more
wiley   +1 more source

Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patients

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race of origin in a global cohort of patients. Methods Retrospective collaborative study of 1426 patients who underwent primary enucleation for retinoblastoma. Results Patients were grouped into Caucasians (n = 231, 16%), Asians (
Swathi Kaliki   +20 more
wiley   +1 more source

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