Results 211 to 220 of about 466,856 (291)

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

Neuropsychiatric Outcomes Associated With GLP‐1 Receptor Agonist Use in Medicare Beneficiaries With Type 2 Diabetes: Variation by Treatment Pattern and Obesity Status

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Glucagon‐like peptide‐1 (GLP‐1) receptors are expressed in brain regions governing mood, reward and stress, yet the neuropsychiatric effects of GLP‐1 receptor agonist (GLP‐1 RA) therapy remain poorly characterized. We estimated associations between GLP‐1 RA use and neuropsychiatric disorders and variation by obesity status and treatment ...
Seo Hyon Baik, Fitsum Baye, Haotian Xian, Kin Wah Fung, Clement J. McDonald   +4 more
wiley   +1 more source

Charting the course of Sjögren's disease: A historical analysis of scientific progress

European Journal of Oral Sciences, EarlyView.
Abstract Sjögren's disease (SjD) bears the name of the Swedish ophthalmologist Henrik Sjögren. His 1933 doctoral thesis on keratoconjunctivitis sicca ignited interest, yet much remains under debate. SjD is an autoimmune disorder that primarily affects the exocrine glands, particularly the salivary and lacrimal glands, leading to a dryness of the eyes ...
Diego Ustárroz Cantali, Fabiola Reis de Oliveira, Denise Cantarelli Machado, Moisés Evandro Bauer   +3 more
wiley   +1 more source

Learning Curve of Pentaspline Pulsed‐Field Ablation With Posterior Wall Isolation for Persistent Atrial Fibrillation

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pentaspline pulsed‐field ablation (PFA) has emerged as a novel modality for pulmonary vein isolation (PVI) and posterior wall isolation (PWI) in persistent atrial fibrillation (AF). However, the learning curve associated with combined PVI + PWI and the contribution of anatomical factors to acute lesion completeness remain ...
Atsuhiko Yagishita, Kazuma Iimura, Aika Iijima, Mari Amino, Yuji Ikari, Koichiro Yoshioka   +5 more
wiley   +1 more source

Treating parents with ADHD and their children (TPAC): a hybrid effectiveness‐implementation, randomized controlled trial

Journal of Child Psychology and Psychiatry, EarlyView.
Background Attention‐Deficit/Hyperactivity Disorder (ADHD) is highly heritable; thus, parents and children frequently experience ADHD‐related impairments. Parent ADHD is associated with poorer developmental and treatment outcomes for children with ADHD, in part due to executive functioning and emotion regulation difficulties that interfere with ...
Andrea Chronis‐Tuscano, Nadia Bounoua, Christina M. Danko, Daniel Almirall, Joyce H.L. Lui, Donna Marschall, Daria Taubin, Hong N.T. Bui, Nicholas P. Marsh, Lisa Efron, Julia Dorfman, Nicole E. Lorenzo, Melissa Dvorsky, Ian M. Bennett, Shireen M. Atabaki, Adelaide S. Robb   +15 more
wiley   +1 more source

Ocular mucous membrane pemphigoid: A retrospective study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Neda Cramer, Johannes Mohr, Rotraut Mössner, Christian van van Oterendorp   +3 more
wiley   +1 more source

Hip Fracture Risk of Lemborexant and Suvorexant in Comparison With Z‐Drugs: A Target Trial Emulation

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Lemborexant and suvorexant are widely used dual orexin receptor antagonists (DORAs) for the pharmacological treatment of insomnia. Although they are generally considered safer than benzodiazepine receptor agonists (Z‐drugs) regarding adverse events including hip fractures, evidence from direct comparisons remains limited. This study
Yuichiro Matsuo, Hayato Yamana, Yusuke Sasabuchi, Hiroki Matsui, Takahide Kohro, Hideo Yasunaga   +5 more
wiley   +1 more source

A large multilobulated cutaneous nodule in infancy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Hannah Wahida, Andy Yan, Stephan Forchhammer   +2 more
wiley   +1 more source

Impact of Limited English Proficiency on Glaucoma Outcomes, Access to Eye Care, and Health Literacy in the NIH All of Us Database

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background To explore the associations between limited English proficiency and glaucoma outcomes, access to eye care, and health literacy in a national database. Methods This cross‐sectional study included participants in the NIH All of Us Research Program with available health records and responses to surveys about language.
Ahmad Santina, Vicki Liu, Allan I. Puran, Timothy Banh, Fei Yu, Victoria L. Tseng, Anne L. Coleman   +6 more
wiley   +1 more source

Chronic Health Condition Trajectories and Multimorbidity in Older Adults With Intellectual Disability: A Brief Report of 15 years of Longitudinal Evidence From IDS‐TILDA

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Adults with intellectual disability experience significant health issues that increase with age. Longitudinal analyses offer important evidence on how the trajectories of these conditions' develop and change. Methods Data were drawn from five waves of IDS‐TILDA, with a nationally representative sample of over 700 adults with ...
Martin McMahon, Aviejay Paul, Catriona Ryan, Louise Lynch, Philip McCallion, Mary McCarron, Eilish Burke   +6 more
wiley   +1 more source