Results 101 to 110 of about 3,633,295 (206)

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Autoimmune Glial Fibrillary Acidic Protein (Gfap) Astrocytopa-Thy Accompanied with Reversible Splenial Lesion Syndrome (RESLES): A Case Report and Literature Review. [PDF]

Brain Sci, 2023
Wang S, Yuan J, Liu J.
europepmc   +1 more source

Kcnv2 E151X Mouse Captures Hallmarks of KCNV2‐Associated Retinal Dystrophy

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background KCNV2‐associated retinopathy is a rare inherited retinal dystrophy caused by variants in the KCNV2 gene, leading to disrupted photoreceptor behaviour and progressive deterioration of vision. Patients have characteristic electroretinography abnormalities, including reduced cone response, delayed and reduced rod response to low light ...
Nermina Xhaferri, Sumit Biswas, Benjamin Davies, Moritz Lindner   +3 more
wiley   +1 more source

Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer's disease and vascular pathology. [PDF]

Alzheimers Dement (Amst), 2022
Shir D, Graff-Radford J, Hofrenning EI, Lesnick TG, Przybelski SA, Lowe VJ, Knopman DS, Petersen RC, Jack CR, Vemuri P, Algeciras-Schimnich A, Campbell MR, Stricker NH, Mielke MM.   +13 more
europepmc   +1 more source

Severe chronic neutrophilic cholangiohepatitis with massive choledocholithiasis and hepatolithiasis in a pony

Equine Veterinary Education, EarlyView.
Summary A 20‐year‐old Camargue pony mare was referred for acute‐onset neurological signs and intermittent colic. Clinical examination revealed obtundation, cranial nerve deficits, head pressing, ventral strabismus and ataxia. Laboratory analyses showed marked hyperammonaemia, hyperbilirubinemia, severe increases in liver enzymes, hypoalbuminaemia and ...
C. Maino, N. Ellero, M. Morini, L. V. Muscatello, S. Sabattini, G. Bettini   +5 more
wiley   +1 more source

Glial Fibrillary Acidic Protein (GFAP)-Expressing Metastatic Carcinoma to the Brain: A Case Report. [PDF]

Cureus
Wang BL, Brown TG, BeDell D, Cameron SE, Chen LL.   +4 more
europepmc   +1 more source

Plasma autoantibodies to glial fibrillary acidic protein (GFAP) react with brain areas according to Braak staging of Parkinson's disease. [PDF]

J Neural Transm (Vienna), 2022
Gschmack E, Monoranu CM, Marouf H, Meyer S, Lessel L, Idris R, Berg D, Maetzler W, Steigerwald F, Volkmann J, Gerlach M, Riederer P, Koutsilieri E, Scheller C.   +13 more
europepmc   +1 more source

Histological manifestations of vitamin A toxicity in the liver

Histopathology, EarlyView.
Analysing clinicopathological data from 1960 to 2025, this study characterizes the spectrum of liver injury associated with chronic vitamin A toxicity. Hepatic stellate cell hypertrophy/hyperplasia and sinusoidal fibrosis emerge as the predominant features, providing a morphological basis for diagnosing vitamin A hepatotoxicity.
Giorgio Cazzaniga, Georg Lietz, Dina G. Tiniakos   +2 more
wiley   +1 more source

Evolution of Concepts Regarding the Diagnostic and Prognostic Significance of Glial Fibrillary Acidic Protein (GFAP)-Positive Extracellular Vesicles. [PDF]

Biomedicines
Yunusova N, Svarovsky D, Panfilova P, Ryabova A, Kaigorodova E, Sidenko E, Gervas P, Molokov A, Kondakova I.   +8 more
europepmc   +1 more source