Results 181 to 190 of about 3,633,295 (206)

Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology.
Cynthia Picard, Gabriel Aumont‐Rodrigue, Isabel Sarty, Julia Loncke, Mélissa Savard, Laurence Maligne‐Bruneau, Judes Poirier, for the PREVENT‐AD research group   +7 more
wiley   +1 more source

Mapping sex‐specific associations of adiposity with age‐related cognitive decline and multimodal Alzheimer's pathology

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION The adiposity–cognition relationship in aging is controversial. This study aimed to assess its sex‐ and age‐specific associations with Alzheimer’s disease (AD) pathology using multimodal biomarkers. METHODS In two longitudinal cohorts (Hubei Memory and Aging Cohort Study [HMACS], n = 2,349; Alzheimer’s Disease Neuroimaging ...
Jingjing Zhang, Dan Liu, Yueran Yang, Xiaoyu Lou, Hongwei Ren, Wei Tan, Yan Zeng, for the Alzheimer's Disease Neuroimaging Initiative, and the Hubei Memory and Aging Cohort Study   +8 more
wiley   +1 more source

Bilateral Orbital Fat Hyperintensity in Early Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report. [PDF]

Neurol Neuroimmunol Neuroinflamm
Ito Y, Ohyama K, Kimura A, Yamashita K, Nakayabu M, Fukami Y, Shimohata T, Katsuno M.   +7 more
europepmc   +1 more source

Synergistic association of insomnia and anxiety with cognitive impairment and dementia in older adults

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We investigated the synergistic effects of comorbid insomnia and anxiety on cognitive impairment and dementia and explored the underlying plasma biomarker mechanisms. METHODS We included adults ≥ 60 years from the cross‐sectional cohort named The Shanghai Action to Prevent Dementia in the Elderly (SHAPE) and used data from the ...
Yan Chen, Qianxi Wang, Ling Li, Shixing Qian, Li Bai, Tih Shih Lee, Shaowei Zhang, Yaping Li, Qianqian Guo, Yang Yang, Feng Yan, Lei Feng, Xia Li   +12 more
wiley   +1 more source

Neurofilament Light Chain in Cerebrospinal Fluid and Blood Identifies Patients With Minimal and Overt Hepatic Encephalopathy. [PDF]

Liver Int
Jonasson E, Grønkjær LL, Jacobsen BG, Olsen DA, Wernberg CW, Kuhle J, Madsen JS, Sejbaek T, Lauridsen MM.   +8 more
europepmc   +1 more source

Respiratory Failure due to Glial Fibrillary Acidic Protein Antibody-Associated Disorders: Recovery Following Plasma Exchange. [PDF]

J Clin Apher
Yokosaki M, Naito H, Yamada H, Sugimoto T, Yamazaki Y, Maruyama H.   +5 more
europepmc   +1 more source

Clinical utility of measuring circulating glial fibrillary acidic protein in severe stroke. [PDF]

Stroke Vasc Neurol
Gjordeni M, Pansell J, Thelin EP, Mazya MV, Pourhamidi K, Lindsberg PJ, Mattila OS, Cooray C.   +7 more
europepmc   +1 more source

Fibroblasts Can Express Glial Fibrillary Acidic protein (GFAP) In Vivo

Journal of Neuropathology and Experimental Neurology, 2001
Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells.
Adriano Aguzzi, Herbert Budka, Till Voigtländer   +2 more
exaly   +2 more sources

Chronic Ethanol-Induced Glial Fibrillary Acidic Protein (GFAP) Immunoreactivity: An Immunocytochemical Observation in Various Regions of Adult Rat Brain

International Journal of Neuroscience, 2009
In the present study, the effects of chronic ethanol (ETOH) treatment on the glial fibrillary acidic protein (GFAP) immunoreactivity was investigated in adult rat brains.
Melda Yardimoglu, Cannur Dalcik, Hakki Dalcik   +2 more
exaly   +2 more sources