Results 101 to 110 of about 127,720 (302)

Segmentation of Gliomas using GLCM Features and Classification of Gliomas in Brain using SVM Classifier

, 2019
Brain Gliomas is one among the biggest threat faced by many people around the globe. According to Inter- national Agency of Research on Cancer (IARC) more than one million people are diagnosed with brain gliomas per year around the globe, with increased ...
Venkatesan. S, Swetha M.D
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

RETRACTED: Pard3 suppresses glioma invasion by regulating RhoA through atypical protein kinase C/NF‐κB signaling

Cancer Medicine, 2019
Partitioning defective protein 3 (Pard3) has been reported to inhibit the progression of numerous human cancer cell types. However, the role of Pard3 in glioma progression remains unclear.
Junjun Li, Hao Xu, Qiangping Wang, Peng Fu, Tao Huang, Omarkhalil Anas, Hongyang Zhao, Nanxiang Xiong   +7 more
doaj   +1 more source

Surgical Management of Incidental Gliomas

, 2017
Detailed brain imaging studies discover gliomas incidentally before clinical symptoms or signs show. These tumors represent an early stage in the natural history of gliomas. Left untreated, they are likely to progress to a symptomatic stage and transform
Noorani, Imran, Nader Sanai, Imran Noorani, Sanai, Nader   +3 more
core   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

A mathematical model describes the malignant transformation of low grade gliomas: Prognostic implications. [PDF]

, 2017
Gliomas are the most frequent type of primary brain tumours. Low grade gliomas (LGGs, WHO grade II gliomas) may grow very slowly for the long periods of time, however they inevitably cause death due to the phenomenon known as the malignant transformation.
Víctor M. Pérez-García, Bogdańska, Magdalena U, Philippe Schucht, Monika J Piotrowska, Víctor M Pérez-García, Monika J. Piotrowska, Schucht, Philippe, Bogdańska, Magdalena, Beck, Jürgen, Piotrowska, Monika J, Michael Murek, Piotrowska, Monika, Bodnar, Marek, Martínez-González, Alicia, Magdalena U. Bogdańska, Murek, Michael, Pérez-García, Víctor M, Jürgen Beck, Alicia Martínez-González, Pérez-García, Víctor M., Magdalena U Bogdańska, Marek Bodnar   +21 more
core   +3 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers [PDF]

, 2010
Background: High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification.
B Bell, Griffiths, John R, Griffiths John R, Fellows, G.A., Wilson, M, Bell, B Anthony, Wright, Alan J, Wilson M, Fellows, Greg A, Howe, F.A., Bell, B.A., John R Griffiths, Wright, AJ, Wright Alan J, Fellows Greg A, Bell, BA, Bell B, Franklyn A Howe, Alan J Wright, Griffiths, JR, Greg A Fellows, Wright, A.J., Wilson, Martin; id_orcid, Griffiths, J.R., Wilson, M., Fellows, GA, Howe, FA, Howe Franklyn A, Howe, Franklyn A, M Wilson   +29 more
core   +2 more sources

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Editorial: Targeting oxidative stress for protecting neurons against injury

Frontiers in Cellular Neuroscience, 2023
Hulya Karatas
doaj   +1 more source