Results 131 to 140 of about 243,135 (270)
Movement Disorders, EarlyView.Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson +5 more
wiley +1 more source
Multimodal Imaging Investigation of the Dentato‐Thalamo‐Cortical Pathway in Friedreich's Ataxia
Movement Disorders, EarlyView.Abstract Background Friedreich's ataxia (FRDA) is a spinocerebellar neurodegenerative disorder. The dentato‐thalamo‐cortical (DTC) pathway, an important cerebellar output involved in motor control, plays a crucial role in the neural mechanisms underlying ataxia symptoms in FRDA.
Yinghua Jing +22 more
wiley +1 more source
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose To achieve high resolution (≤ 1 mm isotropic) whole‐brain perfusion imaging at 7 T with next generation ASL pulse sequence, reconstruction algorithm, and MRI hardware. Methods We capitalized on three major innovations: (1) FLASH‐based pseudo‐Continuous ASL (pCASL) sequence with rotated golden‐angle stack‐of‐spirals (rGA‐SoS) sampling; (
Chenyang Zhao +8 more
wiley +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background Obesity increases the risks and complexity of laparoscopic surgeries. Preoperative very low‐calorie diets (VLCDs) can demonstrate significant preoperative weight loss. However, the optimal VLCD duration remains unclear. Excessive loss of muscle mass associated with VLCDs may elevate surgical and postoperative risks. This study aimed
Gerald Wei Shen Wong +4 more
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective Cholecystectomy (GBX) may alter energy metabolism, but human evidence is limited. We examined whether GBX alters energy expenditure (EE), respiratory exchange ratio (RER), and substrate oxidation. Methods A total of 384 healthy Southwestern Indigenous American adults (222 males, age 28 ± 6 years) were studied, including individuals ...
Beyza N. Aydin +6 more
wiley +1 more source
Time to burn: landscape drivers of fuel trait variability and fire regime in savanna ecosystems
Oikos, EarlyView.Fuel traits are important determinants of fire behavior and regime in savannas and, thus, of how fire affects plant communities. However, whether these traits are correlated, predictable and how they are influenced by biotic and abiotic drivers remain to be rigorously evaluated.
Waleska B. F. Manzan +2 more
wiley +1 more source
Empirical optimization of dual-sgRNA design for in vivo CRISPR/Cas9-mediated exon deletion in mice. [PDF]
Comput Struct Biotechnol JLee SY +9 more
europepmc +1 more source
Oikos, EarlyView.Seasonal environmental cycles affect plant–pollinator interactions by altering plant phenology. Periods of low resource availability can filter pollinators and reduce the complexity of interaction networks, but the extent to which the functional morphology of pollinators influences such filtering remains unclear.
Ugo M. Diniz +3 more
wiley +1 more source
Expert‐led priorities for a response diversity research agenda in ecology
Oikos, EarlyView.Response diversity describes variation in ecological responses to environmental change. Response diversity is expected to drive ecological stability since a wider variety of responses to one or more environmental factors should stabilise fluctuations of ecosystem functions. However, uptake of empirical response diversity research has been slow. Here we
Samuel R. P.‐J. Ross +7 more
wiley +1 more source