Results 81 to 90 of about 1,205,286 (276)

Computational methods for global/local analysis [PDF]

Computational methods for global/local analysis of structures which include both uncoupled and coupled methods are described. In addition, global/local analysis methodology for automatic refinement of incompatible global and local finite element models ...
Aminpour, Mohammad A., Knight, Norman F., Jr., Mccleary, Susan L., Ransom, Jonathan B.   +3 more
core   +1 more source

Does regional development explain international youth mobility? Spatial patterns and global/local determinants of the recent emigration of young Italians [PDF]

, 2018
In this essay, we tackle the issue of the international mobility of young Italians in relation to regional disparities. Our intention is to determine if and to what extent a relationship exists between regional development and the international mobility ...
Benassi, Federico, Staniscia, Barbara
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Understanding and supporting community-led protection

Forced Migration Review, 2016
Supporting locally led protection strategies can significantly improve the impact of protection interventions. External actors first need to acknowledge the capacity of people at risk as independent actors themselves.
Nils Carstensen
doaj  

Assessing the psychometric properties and validating the Portuguese version of the INSPIRE measure of staff support for personal recovery in Portugal

BMC Psychiatry
Background The importance of mental health services that support a recovery-oriented approach is increasingly recognized, and measures that evaluate this practice and promote change over time are needed.
Manuela Silva, Deborah Oyine Aluh, Ana Lourenço, Beatriz Resende, Francisco Agostinho, João Bessa Rodrigues, João Pedro Azenha, João Revez Lopes, Marta Ribeiro, Maria João Heitor, Joaquim Gago, Graça Cardoso   +11 more
doaj   +1 more source

Fluidisation and plastic activity in a model soft-glassy material flowing in micro-channels with rough walls

, 2016
By means of mesoscopic numerical simulations of a model soft-glassy material, we investigate the role of boundary roughness on the flow behaviour of the material, probing the bulk/wall and global/local rheologies.
Bernaschi, Massimo, Lulli, Matteo, Sbragaglia, Mauro, Scagliarini, Andrea   +3 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

EL ESCENARIO GLOBAL – LOCAL: NISSAN EN AGUASCALIENTES [PDF]

, 2018
El presente trabajo tiene por objetivo mostrar un acercamiento a la industria automotriz en específico la trasnacional Nissan japonesa en Aguascalientes y el tipo de relación con el desarrollo local a partir de un escenario global en la entidad.
Escobedo Torres, Cecilia, Souza Mosqueda, Leticia Elizabeth   +1 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source