Results 111 to 120 of about 12,335,014 (292)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
On the conformal group of a globally hyperbolic spacetime [PDF]
arXivThe Groups of causal and conformal automorphisms of globally hyperbolic spacetimes were studied. In two dimensions, we prove that all globally hyperbolic spacetimes that are directed and connected are causally isomorphic. We work out the consequences of this fact and obtain a (partial) classification of the causal automorphism and conformal groups of
arxiv
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2020 This paper uses Martin Luther and Mao Zedong's translation strategies to philosophize anew the dialectic between the national and the global in the history of revolutions.
Sinkwan Cheng
doaj
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Global assessment of accountability in water and sanitation services using GLAAS data
Water Alternatives, 2018 The Global Analysis and Assessment of Sanitation and Drinking-Water (GLAAS) is one of UN-Water’s regular reports. Its focuses include aspects of investment and the enabling environment for the delivery of water, sanitation and hygiene services ...
Alejandro Jiménez, +4 more
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Toward a social compact for digital privacy and security [PDF]
Executive summary The Global Commission on Internet Governance (GCIG) was established in January 2014 to articulate and advance a strategic vision for the future of Internet governance. In recent deliberations, the Commission discussed the potential for
Global Commission on Internet Governance
core
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Uniciencia, 1987 El presente trabajo utiliza un modelo atmosférico propuesto por Bárbaro et al. (1979) para el cálculo de la radiación solar global por medio de estimaciones de las componentes directa y difusa, en Limón y Puntarenas, Costa Rica, con base en datos ...
Jaime Wright Gilmore
doaj