Results 111 to 120 of about 14,862,239 (364)

Estudo das relações entre: radiação solar global, radiação líquida, insolação [PDF]

, 1900
José Carlos Ometto
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Globalization and Global History

, 2012
"Globalizations, Global Histories, and Globalizations" Barry K. Gills and William R. Thompson "Globalizing History and Historicising Globalization" Jerry H. Bentley "The Global Animus : In the Tracks of Historical Consciousness" Roland Robertson and David Inglis "Civilizing Processes and International Societies" Andrew Linklater "Globalizations: The ...
Barry K. Gills, William R. Thompson
openaire   +3 more sources

Global assessment of accountability in water and sanitation services using GLAAS data

Water Alternatives, 2018
The Global Analysis and Assessment of Sanitation and Drinking-Water (GLAAS) is one of UN-Water’s regular reports. Its focuses include aspects of investment and the enabling environment for the delivery of water, sanitation and hygiene services ...
Alejandro Jiménez,, John Livsey, Imenne Åhlén, Cecilia Scharp, Marina Takane   +4 more
doaj  

Global Frontiers of Public Health [PDF]

, 1945
Thomas Parran
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The Birds Understood Global Geography before We Did! Migration Routes of Birds [PDF]

, 1945
Donald S. Lacroix
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Aplicaciones del modelo de BARBARO et al. para el cálculo de la radiación solar global por medio de estimaciones de las componentes directa y difusa, en Limón y Puntarenas, Costa Rica, para el período 1970-1972

Uniciencia, 1987
El presente trabajo utiliza un modelo atmosférico propuesto por Bárbaro et al. (1979) para el cálculo de la radiación solar global por medio de estimaciones de las componentes directa y difusa, en Limón y Puntarenas, Costa Rica, con base en datos ...
Jaime Wright Gilmore
doaj  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source