Results 141 to 150 of about 14,862,239 (364)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Trade with Canada: A Tennessee Update [PDF]

open access: yes
international, trade, regional, exports ...
Steven G. Livingston
core  

Global Public Goods and Global Health [PDF]

open access: yes, 2012
The repair rate on electron beam welded diaphragm hasn’t been at the desired level at Siemens SIT for several years. An improvement program the past five years has reduce the repair rate from 60% to 12-15% but the goal of 5% repair rate hasn’t been met ...
Gartner, David
core   +1 more source

The Mental Capacity Act: 10 years on – the key learning areas for healthcare professionals

open access: yesNursing: Research and Reviews, 2018
Helen Marshall,1 Sally Sprung2 1Mersey Care NHS Foundation Trust, Liverpool, UK; 2School of Nursing and Allied Health, Liverpool John Moores University, Liverpool, UK Abstract: The Mental Capacity Act (MCA) became statute law in England and Wales from ...
Marshall H, Sprung S
doaj  

TESTS OF THE EFFECT OF GRID RESOLUTION IN A GLOBAL PREDICTION MODEL [PDF]

open access: bronze, 1969
M. S. V. Rao, L. J. Umscheid
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

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