Results 201 to 210 of about 18,530,294 (403)
MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song +11 morewiley +1 more sourceChemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more sourceRising military spending jeopardizes climate targets. [PDF]
Nat CommunDong W, Ran Q, Liu F, Deng R, Yang J, Wang K, Wang X, Zheng D, Li C, Liang W, Chou J, Yuan W, Chen D. +12 moreeuropepmc +1 more sourceGlobal, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet, 2020 Boris Caroline A Andrew S Mari Amir Molla Oladimeji M Mo Bikbov Purcell Levey Smith Abdoli Abebe Adebayo Af, B. Bikbov, Caroline A. Purcell, A. Levey, Mari Smith, Amir Abdoli, Molla Abebe, O. Adebayo, M. Afarideh, Sachin Agarwal, Marcela Agudelo-Botero, E. Ahmadian, Z. Al-Aly, V. Alipour, A. Almasi-Hashiani, Rajaa Al-Raddadi, N. Alvis-Guzmán, S. Amini, Tudorel Andrei, C. Andrei, Zewudu Andualem, Mina Anjomshoa, J. Arabloo, A. Ashagre, Daniel Asmelash, Z. Ataro, Maha Moh’d Wahbi Atout, M. Ayanore, A. Badawi, A. Bakhtiari, S. Ballew, A. Balouchi, Maciej Banach, S. Barquera, Sanjay Basu, Mulat Tirfie Bayih, Neeraj Bedi, A. Bello, I. Benseñor, Ali Bijani, A. Boloor, A. Borzì, L. Cámera, J. Carrero, F. Carvalho, Franz Castro, F. Catalá-López, Alex R. Chang, K. Chin, Sheng-Chia Chung, Massimo Cirillo, Ewerton Cousin, L. Dandona, R. Dandona, A. Daryani, R. Das Gupta, F. M. Demeke, Gebre Teklemariam Demoz, Desilu Mahari Desta, H. Do, B. Duncan, A. Eftekhari, A. Esteghamati, S. S. Fatima, João Fernandes, E. Fernandes, F. Fischer, M. Freitas, M. Gad, Gebreamlak Gebremedhn Gebremeskel, B. M. Gebresillassie, Birhanu Geta, M. Ghafourifard, A. Ghajar, N. Ghith, P. Gill, I. Ginawi, R. Gupta, N. Hafezi-Nejad, Arvin Haj-Mirzaian, A. Haj-Mirzaian, Ninuk Hariyani, M. Hasan, Milad Hasankhani, A. Hasanzadeh, H. Y. Hassen, Simon Iain Hay, B. Heidari, C. Herteliu, C. L. Hoang, M. Hosseini, M. Hostiuc, S. Irvani, S. Islam, Nader Jafari Balalami, S. James, S. Jassal, V. Jha, J. Jonas, F. Joukar, J. Jozwiak, Alia Kabir, Amaha Kahsay, A. Kasaeian, T. Kassa, Hagazi Gebremedhin Kassaye, Yousef S. Khader, Rovshan Khalilov, E. Khan, M. S. Khan, Y. Khang, A. Kisa, C. Kovesdy, B. Kuate Defo, G. Kumar, A. Larsson, L. Lim, Alan D. Lopez, P. Lotufo, A. Majeed, R. Malekzadeh, Winfried März, Anthony Masaka, H. Meheretu, T. Miazgowski, Andreea Mirica, E. Mirrakhimov, P. Mithra, B. Moazen, D. K. Mohammad, R. Mohammadpourhodki, S. Mohammed, A. Mokdad, Linda Morales, Ilais Moreno Velásquez, Seyyed Meysam Mousavi, S. Mukhopadhyay, J. Nachega, Girish N. Nadkarni, J. R. Nansseu, G. Natarajan, J. Nazari, B. Neal, R. Negoi, C. Nguyen, Rajan Nikbakhsh, J. Noubiap, C. Nowak, A. Olagunju, Alberto Ortiz, M. Owolabi, R. Palladino, M. Pathak, H. Poustchi, S. Prakash, N. Prasad, A. Rafiei, S. Raju, K. Ramezanzadeh, S. Rawaf, D. Rawaf, Lal B Rawal, R. Reiner, A. Rezapour, D. Ribeiro, L. Roever, D. Rothenbacher, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Saeed Safari, B. Sahle, Hosni Salem, J. Sanabria, I. Santos, A. Sarveazad, M. Sawhney, E. Schaeffner, M.I. Schmidt, A. Schutte, S. Sepanlou, M. Shaikh, Z. Sharafi, M. Sharif, Amrollah Sharifi, D. Silva, Jasvinder A. Singh, N. P. Singh, M. M. Sisay, A. Soheili, I. Sutradhar, B. Teklehaimanot, B. E. Tesfay, Getnet Teshome, J. Thakur, M. Tonelli, Khanh B. Tran, B. Tran, Candide Tran Ngoc, I. Ullah, Pascual Valdez, S. Varughese, T. Vos, L. G. Vu, Yasir Waheed, A. Werdecker, H. F. Wolde, A. Wondmieneh, Sarah Wulf Hanson, Tomohide Yamada, Yigizie Yeshaw, N. Yonemoto, H. Yusefzadeh, Z. Zaidi, Leila Zaki, S. Zaman, N. Zamora, A. Zarghi, Kaleab Alemayehu Zewdie, J. Ärnlöv, J. Coresh, N. Perico, G. Remuzzi, C. Murray, T. Vos +223 moresemanticscholar +1 more source
