Results 61 to 70 of about 14,862,239 (364)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Global health and global bioethics
Cadernos Ibero-Americanos de Direito Sanitário, 2021 Covid-19 is not merely a national or regional threat but a global one. It requires coordinated action of the global community. Such action, as argued in this paper, should primarily focus on the question how to prevent the next pandemic. Humankind has been warned multiple time for emerging diseases and the risks of pandemics, although no preparatory ...
openaire +5 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Tuberculosis. A Global Study in Social Pathology [PDF]
, 1950 Eugene L. Opie
openalex +2 more sources
Strengthening the policy setting process for global malaria control and elimination
Malaria Journal, 2012 The scale-up of malaria control efforts in recent years, coupled with major investments in malaria research, has produced impressive public health impact in a number of countries and has led to the development of new tools and strategies aimed at further
D'Souza Bianca J, Newman Robert D
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Global Goals and Global Sustainability [PDF]
International Journal of Environmental Research and Public Health, 2016 On 25 September 2015, the United Nations (UN) member countries adopted an ambitious 17 Sustainable Development Goals (SDGs) aiming to ‘transform the world’ in the next 15 years. [...]
openaire +3 more sources
Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase
FEBS Letters, EarlyView.The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu +5 more
wiley +1 more source
Revista IBRACON de Estruturas e Materiais, 2020 The global stability of tall reinforced concrete buildings made up of flat slabs is guaranteed, among other factors, by the existence of considerably rigid elements such as elevator cores and stairways.
E. C. ALVES, L. A. FEITOSA
doaj +2 more sources