Results 61 to 70 of about 3,430,077 (261)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Probabilistic global maps of crop-specific areas from 1961 to 2014
Environmental Research Letters, 2019 Agriculture has substantial socioeconomic and environmental impacts that vary between crops. However, information on how the spatial distribution of specific crops has changed over time across the globe is relatively sparse.
Nicole D Jackson +3 more
doaj +1 more source
Understanding the Global Sensory Landscape for Facial Cleansing/Makeup Remover Wipes
Cosmetics, 2019 Makeup chemistries have evolved over the recent years and have become more long-wearing, waterproof and difficult to remove. Thus, many changes have occurred among products designed to remove makeup.
Huajing Xing +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mapping and analysing cropland use intensity from a NPP perspective
Environmental Research Letters, 2016 Meeting expected surges in global biomass demand while protecting pristine ecosystems likely requires intensification of current croplands. Yet many uncertainties relate to the potentials for cropland intensification, mainly because conceptualizing and ...
Maria Niedertscheider +6 more
doaj +1 more source
Global Challenges, Global Opportunities
Annals of Global Health, 2014 Academia is at an exciting crossroads. The global problems we face are immense, but the good news is we know how to address most of them. Our primary challenge today is not a lack of knowledge but a failure to scale up what we already know works. Some of the skills to implement what we know are medical, many are not.
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Big Earth Data, 2019 Multi-temporal, globally consistent, high-resolution human population datasets provide consistent and comparable population distributions in support of mapping sub-national heterogeneities in health, wealth, and resource access, and monitoring change in ...
Christopher T. Lloyd +13 more
doaj +1 more source