Results 81 to 90 of about 1,478,682 (342)

Escaping the Vicious Cycle of Poverty: Towards Universal Access to Energy. CEPS Working Document No. 363, 9 March 2012 [PDF]

, 2012
Despite the continuous efforts of developing countries and the international community to reduce energy poverty, some 2.7 billion people around the world still rely on traditional biomass for cooking and heating and 1.3 billion people do not have access ...
Ferrer, Jorge Núñez, Lahn, Glada, Behrens, Arno., Dreblow, Eike, Veit, Sebastian, Carraro, Mathilde   +5 more
core  

Assessing tuberculosis infection prevalence and test concordance in high-risk groups: a cross-sectional study in Mexicali, Baja California

BMJ Open
Background Despite low sensitivity and implementation challenges, the tuberculin skin test (TST) remains the standard-of-care tuberculosis (TB) infection test in Mexico. Interferon gamma release assays (IGRA) may overcome TST-related challenges.
Mildred Lee, Meredith B Brooks, Tom Nicholson, Amanda Brumwell, Rosa Herrera, Kevin Contreras, Eduardo Becerra, Julia Estrada-Guzmán, Rene Machado Contreras   +8 more
doaj   +1 more source

Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa

eLife, 2019
Local and cross-border importation remain major challenges to malaria elimination and are difficult to measure using traditional surveillance data. To address this challenge, we systematically collected parasite genetic data and travel history from ...
Sofonias Tessema, Amy Wesolowski, Anna Chen, Maxwell Murphy, Jordan Wilheim, Anna-Rosa Mupiri, Nick W Ruktanonchai, Victor A Alegana, Andrew J Tatem, Munyaradzi Tambo, Bradley Didier, Justin M Cohen, Adam Bennett, Hugh JW Sturrock, Roland Gosling, Michelle S Hsiang, David L Smith, Davis R Mumbengegwi, Jennifer L Smith, Bryan Greenhouse   +19 more
doaj   +1 more source

When health data go dark: the importance of the DHS Program and imagining its future

BMC Medicine
The suspension and/or termination of many programmes funded through the United States Agency for International Development (USAID) by the new US administration has severe short- and long-term negative impacts on the health of people worldwide.
J. J. Khaki, J. Molenaar, Sulata Karki, E. Olal, M. Straneo, M. Mosuse, Jovanny Tsuala Fouogue, Bernadette Hensen, A. Baguiya, Angèle Musau Nkola, Kerry L. M. Wong, Oumar Aly Ba, A. Kikula, F. M. Grovogui, A. Semaan, A. Asefa, P. Macharia, C. D. Chikwari, M. Ouédraogo, A. Christou, E. Okiro, M. Mutua, A. Amodu, M. Phiri, Rukundo Athanase, D. Kitara, O. Owolabi, A. Pembe, B. Afolabi, Lenka Beňová   +29 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Treatment Access for Gastrointestinal Stromal Tumor in Predominantly Low- and Middle-Income Countries

JAMA Network Open
Key Points Question Can oral anticancer therapy be distributed to patients with acceptable clinical outcomes through a global access program for the treatment of gastrointestinal stromal tumor (GIST)? Findings In this cohort study of 12 015 patients, the
Edward Briercheck, J. Wrigglesworth, Inés García-González, Catherina Scheepers, Mei Ching Ong, Viji Venkatesh, Philip Stevenson, A. Annamalay, D. Coffey, Aparna B. Anderson, Pat Garcia-Gonzalez, Michael Wagner   +11 more
semanticscholar   +1 more source

Novel Humanitarian Aid Program: The Glivec International Patient Assistance Program—Lessons Learned From Providing Access to Breakthrough Targeted Oncology Treatment in Low- and Middle-Income Countries

Journal of Global Oncology, 2015
Imatinib was the first targeted therapy approved for the treatment of cancer. With its approval, it was immediately clear to Novartis that this breakthrough therapy would require an innovative approach to worldwide access, with special consideration of ...
Pat Garcia-Gonzalez, Paul G. Boultbee, D. Epstein   +2 more
semanticscholar   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Landscape analysis of pregnancy exposure registries in low- and middle-income countries: a scoping review

BMJ Open
Introduction Drug and vaccine safety information relevant to pregnant individuals is typically insufficient, especially so for persons living in low- and middle-income countries (LMICs).
Esperanca Sevene, Jessica Mooney, Smaragda Lamprianou, Niranjan Bhat, Andy Stergachis, Shanthi N Pal, Rahmeh AbuShweimeh, Sophie Knudson, Deshayne Fell, Hilma Nakambale, Nancy Salts, Ushma C Mehta   +11 more
doaj   +1 more source

Public health interventions to improve access and quality of care for patients with acute cardiac events: Overview of the HeartRescue China program

Cardiology Plus, 2016
Cardiovascular diseases (CVDs) remain the biggest cause of deaths worldwide. More than 17 million people die from CVDs annually. The HeartRescue Global Program is a five-year international healthcare program, sponsored by Medtronic Philanthropy and its ...
Feng Liu, Lin Zhang, Min Ge, Jian Xing, Bingquan You, Xianghui Zhang, Oumin Shi, Bentley Bobrow, Kenneth A LaBresh, Michael G Trisolini, Zhijie Zheng   +10 more
doaj   +1 more source