Results 121 to 130 of about 1,551,737 (267)

Promise to Practice: Reimagining Artificial Intelligence for Equitable Global Health Impact. [PDF]

Ann Glob Health
Patel S, Robsky KO, Mao W, Usman U, Garcia L, Omobowale O, Mchunu G, Sung J, Clifford G, Madabhushi A, Ismail A, Bidiwala S, Mehmood S, Ngaruiya C, Kilgore PE, Martin K.   +15 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Toward a biopsy-free approach: cardiac magnetic resonance T1 mapping for detecting heart transplant rejection. [PDF]

Eur Heart J Cardiovasc Imaging
Taipale M, Pentikäinen M, Martelius L, Mutka A, Kytölä S, Kankainen M, Peltonen JI, Syrjälä S, Lahtiharju A, Lommi J, Jahnukainen T, Lemström K, Ojala T.   +12 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Understanding US-based Clinician Participation in Global Pediatric Hematology-Oncology Work: A Mixed-Methods Study. [PDF]

Ann Glob Health
Carpenter K, Shrivastava N, Revette AC, Archer N.   +3 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Correction: The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders. [PDF]

Neuropsychopharmacology
Lavretsky H, Khalsa S, Oughli HA, Ibanez A, Cruzat J, Edwards E, Newhouse P, Bassetti CLA, Begue I, Winkler AS, Jeste DV, Eyre HA.   +11 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Transforming global water cycle observations via synergistic AI and remote sensing. [PDF]

Sci Adv
Yao Z, Cui Y, Jin Z, Wu S, Guo Q, Xu Y, Guo Z, Jiang C, Qu Y, Zhai D, Fan W.   +10 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source