Results 191 to 200 of about 1,551,737 (267)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Defining Recurrent Lumbar Disc Herniation (RLDH): An International Survey Study. [PDF]

Global Spine J
Harhangi JS, Boeykens A, Dos Santos Rubio EJ, Morgenstern C, Burkhardt BW, Datar G, Lewandrowski KU, Harhangi BS.   +7 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Reliability and validation of the German WHOQOL-BREF in adults with congenital heart disease. [PDF]

Qual Life Res
Schröder D, Nebel L, Le Butt TR, Sadlonova M, Herrmann-Lingen C, Krause U, Broschmann D, Dellas C.   +7 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Using oral and parenteral formulation of AWaRe antibiotics as a proxy estimate of community and hospital healthcare sector use. [PDF]

JAC Antimicrob Resist
Lim C, Pauwels I, Nguyen HQ, Cuningham W, Thorn M, Cook A, Swe MMM, Cooper BS, Huttner B, Hsia Y, Moore CE, Vlieghe E, Pouwels KB, Versporten A, Sharland M.   +14 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Planar tetracoordinate oxygen stabilized within triel-chalcogen dicationic frameworks. [PDF]

RSC Adv
Motta L, Cuellar J, García-Argote W, Sacanamboy DS, Roman-Ventura V, Espinoza-Gomez V, Inostroza D, Leyva-Parra L, Tiznado W.   +8 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Longitudinal assessment of myocardial involvement in PASC-CVS: a single-center study from China based on multiparametric CMR. [PDF]

Front Cardiovasc Med
Shang A, Yang S, Tao J, Shen J, Zhan Y, Gan Y, Zhang Z, Jin H, Shan F.   +8 more
europepmc   +1 more source