Results 221 to 230 of about 4,759,858 (314)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

New study on increasing homogeneity within global food supplies warns of serious implications for farming and human nutrition: worldwide spread of a standard globalized diet is putting more food on the dinner table, but at the expense of diverse local crops; global uniformity heightens the risk of food crises due to climate change [PDF]

, 2015
CGIAR, Global Crop Diversity Trust, International Center for Tropical Agriculture   +2 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Editorial: Sustainable management of <i>Tuta absoluta</i>. [PDF]

Front Plant Sci
Omar AA, Ajene IJ, Aslam HMU, Khamis FM.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Acute Rheumatic Fever Diagnostic Network (ARC Network) clinical recruitment protocol. [PDF]

BMJ Open
Fall N, Bowen AC, Buonfiglio S, Francis JR, Gorman C, Fonseca Mendoza R, Fernandes E, Moreland NJ, Pereira Nunes MC, Sable C, Sadiq M, Shannon CP, Parks T, Ralph A, Sanyahumbi A, Sarnacki R, Tebbutt S, Webb R, Carapetis J, Beaton AZ, ARC Diagnostic Network.   +20 more
europepmc   +1 more source

Center for Global Trade Analysis

, 2023
Purdue University Office of Research, van der Mensbrugghe, Dominique   +1 more
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Advancing Global Health Education: Preparing Emergency Medicine Trainees for Low-Resource Settings Through Simulation-Based Training. [PDF]

MedEdPORTAL
Jett J, Alberts HJ, Brown HA, Gainey C, Skaggs J.   +4 more
europepmc   +1 more source