Results 111 to 120 of about 4,024,335 (308)
South Asia and societal challenges : a regional perspective [PDF]
, 2015 This paper is a summary of the South Asian region’s status and interests concerning the seven thematic societal challenges identified under the EU’s Horizon 2020 research programme: Health, demographic change and wellbeing; Food security, sustainable ...
Amaratunga, Dilanthi +3 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Образование и наукаIntroduction. Global problems of modernity and globalisation are appealing to scientists as a research subject not only for understanding their nature, development, and manifestations in various spheres of life (in the case of our study, in education ...
S. N. Sinegubov +4 more
doaj +1 more source
Open for Whom? Equity in Open Knowledge [PDF]
, 2019 This display was created as part of Musselman Library\u27s Open Access Week 2019 programming and highlights challenges and opportunities within the global open access ...
Scholarly Communications, +1 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
How can Sub-Saharan Africa turn the China-India threat into an opportunity [PDF]
, 2009 The rise of China and India – the Asian Driver economies – is transforming the global economic, political and social landscape. The challenges posed by their rapid growth and global emergence are increasingly at the centre of strategic debates in the ...
Kaplinsky, Raphael
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The importance of fungi and of mycology for a global development of the bioeconomy
IMA Fungus, 2012 The vision of the European common research programme for 2014–2020, called Horizon 2020, is to create a smarter, more sustainable and more inclusive society.
L. Lange +9 more
doaj