Results 141 to 150 of about 933,426 (267)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Financing Climate Mobility – from Duty to Investment

AJIL Unbound
Katerina Linos
doaj   +1 more source

Ecosystem technology (ecotech): Harnessing natural processes to address global challenges. [PDF]

Sci Adv
Silliman BR, Hensel MJS, Temmink RJM, Paxton AB, Wieczynski DJ, Gibert JP, Johnston DW, Noonan D, Ferris WN, Hay ME, Paalman T, Cutshaw C, Borsuk M, Angelini C, Dalton LE, van de Koppel J, van Belzen J, Strong B, Bertness MD, Angelini TE, Gutierrez AW, Thomsen MS, Kaynor T, Olander L, Cassar N, Stoorvogel MM, Bouma TJ, Wear S, van der Heide T, Daleo P, Parker S, Aithal A, Gittman RK, Silliman P, Wade E, Rungta D, Qiu T, He L, Cerino DS, He Q, von Windheim J, Nordone SK.   +41 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

An Ever-Stronger Union: Introduction to the Symposium

AJIL Unbound
Elena Kempf, Katerina Linos
doaj   +1 more source

Placenta Accreta Spectrum: A Narrative Review of Clinical Management, Contemporary Innovations, And Global Challenges. [PDF]

Int J Med Sci Dent Health
Ezeigwe CO, Eleje GU, Eze UP, Igwemadu GT, Ugwu EO, Egwuatu EC, Okafor CG, Okoro CC, Onyejiaka CC, Nnabuchi OK, Okam PC, Egwim AV, Oguejiofor CB, Nwankwo ME, Okeke CA, Chigbo CG, Udigwe GO, Ikechebelu JI, Ubom AE, Nwaogu KC, Eke AC.   +20 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

"Overview of Global Challenges in Dealing with Neonatal Sepsis and Responsibility of Healthcare Workers": A Narrative Review. [PDF]

Indian J Community Med
Ravikoti S, Bhatia V, Kuppuswamy MS.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Quality of care in an era of global challenges: a transformational vision for WHO European Region and beyond. [PDF]

Eur J Public Health
Fonseca VR, Ivanković D, Maliqi B, Klazinga N, Larsson S, Kuipers EJ, Triantafyllou C, Hall J, Vildiridi L, Permanand G, Azzopardi Muscat N, Breda J.   +11 more
europepmc   +1 more source