Results 61 to 70 of about 4,024,335 (308)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
GLOBAL CHALLENGES: LOCAL ISSUES [PDF]
International Development,
Hedley, Douglas D.
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Globalization and global challenges
, 2015 ln the lightof recent politicaland financial instabilities, there has been an increasing trend of doubt towards current monetary systems around the globe. The introduction of digital currencies, such as Bitcoin fueled the debate over the potential advantages and disadvantages these currencies might bring.
Ussembekova, Altynay +2 more
openaire +3 more sources
NGEU: A New Marshall Plan for Europe and a Template for Global Finance
AJIL UnboundIn April 2020, President of the European Commission Ursula von der Leyen called for a “Marshall Plan for Europe.”1 Almost a year after her appeal, the European Union implemented the recovery and resilience program Next Generation EU (NGEU). NGEU, we show,
Elena Kempf, Katerina Linos
doaj +1 more source
Global challenges and globalization of bioethics [PDF]
Croatian Medical Journal, 2013 This article analyzes problems and implications for man and nature connected with the formation of a new architecture of science, based on the convergence of nanotechnology, biotechnology, information technology, and cognitive science (NBIC). It also describes evolution and genesis of bioethics, a scientific discipline and social practice with a ...
openaire +2 more sources
70 Years of Human Rights in Global Health: Drawing on a Contentious Past to Secure a Hopeful Future [PDF]
, 2018 The Universal Declaration of Human Rights, adopted on Dec 10, 1948, established a modern human rights foundation that has become a cornerstone of global health, central to public health policies, programmes, and practices.
Ghebreyesus, Tedros A. +4 more
core +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source