Results 51 to 60 of about 2,243,884 (354)
Complex networks in climate dynamics - Comparing linear and nonlinear network construction methods
, 2009 Complex network theory provides a powerful framework to statistically investigate the topology of local and non-local statistical interrelationships, i.e. teleconnections, in the climate system.
Donges, Jonathan F. +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Characterization of thermal structure and conditions for overshooting of tropical and extratropical cyclones with GPS radio occultation [PDF]
Atmospheric Chemistry and Physics, 2015 The thermal structure of tropical cyclones (TCs) in different ocean basins is studied using global positioning system (GPS) radio occultation (RO) measurements co-located with TCs' best tracks.
R. Biondi +3 more
doaj +1 more source
Atmosphere, 2021 The work is devoted to the study of the climatic effects of black carbon (BC) transferred from forest fires to the Arctic zone. The HYSPLIT (The Hybrid Single-Particle Lagrangian Integrated Trajectory model) trajectory model was used to initially assess ...
Sergey Kostrykin +5 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Climate intercomparison of GPS radio occultation, RS90/92 radiosondes and GRUAN from 2002 to 2013 [PDF]
Atmospheric Measurement Techniques, 2015 Observations from the GPS radio occultation (GPSRO) satellite technique and from the newly established GCOS Reference Upper Air Network (GRUAN) are both candidates to serve as reference observations in the Global Climate Observing System (GCOS ...
F. Ladstädter +3 more
doaj +1 more source
Implications of and possible responses to climate change [PDF]
, 2009 Climate change is expected to worsen food insecurity and seriously undermines rural development prospects. It makes it harder to achieve the Millenium Development Goals and ensure a sustainable future beyond 2015.
Kahiluoto, Helena, Rötter, Reimund
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Influence of changes in humidity on dry temperature in GPS RO climatologies [PDF]
Atmospheric Measurement Techniques, 2014 Radio occultation (RO) data are increasingly used in climate research. Accurate phase (change) measurements of Global Positioning System (GPS) signals are the basis for the retrieval of near-vertical profiles of bending angle, microwave refractivity,
J. Danzer +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source