Results 171 to 180 of about 2,103,834 (306)

The Multilateral Response to the Global Crisis: Rationale, Modalities, and Feasibility [PDF]

The paper reviews the case for a strong multilateral response to the global crisis in emerging markets (EMs). It discusses modalities and feasibility of intervention and its associated risks, depending on country circumstances of fiscal space and ...
Alessandro Rebucci, Andrew Powell, Eduardo Fernandez-Arias   +2 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Too young to pour: the global crisis of underage alcohol use. [PDF]

Front Public Health
Esposito S, Campana BR, Argentiero A, Masetti M, Fainardi V, Principi N.   +5 more
europepmc   +1 more source

The Rise of Vectored Vaccines: A Legacy of the COVID-19 Global Crisis. [PDF]

Vaccines (Basel), 2021
Daian E Silva DSO, da Fonseca FG.
europepmc   +1 more source

SUSTAINABLE DEVELOPMENT IN THE GLOBAL ECONOMY [PDF]

The actual paper comes with an approach regarding the sustainable development in today’s world and the global economy. The way of proceeding is the following: the main causes of the current economic crisis are analyzed and it is demonstrated that ...
Drd. Anagnoste Sorin, Prep. Univ. Drd. Agoston Simona   +1 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

How Is Colorectal Cancer Care Impacted by Global Crisis in Contrasting Healthcare Systems?-A Descriptive Study From Scotland and Switzerland During the COVID-19 Pandemic. [PDF]

World J Surg
Wiesler B, Worni M, Studer P, Gass JM, Metzger J, Hartel M, Nebiker C, Rosenberg R, Galli R, Eisner L, Andreou C, Zingg U, Stimpfle D, Viehl CT, Müller A, Müller B, Denhaerynck K, Hall P, Gallagher C, Karunaratne P, Lilley C, Zuber M, Paterson H, von Strauss Und Torney M.   +23 more
europepmc   +1 more source

Student adaptability, emotions, and achievement: Navigating new academic terrains in a global crisis. [PDF]

Learn Individ Differ, 2021
Stockinger K, Rinas R, Daumiller M.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Obsessive trajectories in children and adolescents exposed to adverse events (coronavirus disease 2019: global crisis teaches). [PDF]

Front Psychol
Demaria F, Pontillo M, Bertoncini I, Vicari S.   +3 more
europepmc   +1 more source