Results 41 to 50 of about 7,239,737 (307)

CPEC: A Game Changer in the Balance of Power in South Asia [PDF]

China Quarterly of International Strategic Studies, 2018
Intended as a pilot flagship project under the Chinese-led Belt and Road Initiative (BRI), the China-Pakistan Economic Corridor (CPEC) has received relatively positive responses from actors in and outside the South Asian region. Islamabad, New Delhi, and
Zahid Khan, Guo Changgang, Riaz Ahmad, Fang Wenhao   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Global viewing in East London [PDF]

European Journal of Cultural Studies, 2007
This article engages with the understandings, responses and news viewing frameworks of young multi-ethnic, working-class Londoners following the war in Iraq and the so-called 'War on Terror'. Is television news itself viewed as a monolithic entity, either in its own right or as the mouthpiece of whichever regime is in power? Are some viewers more prone
openaire   +3 more sources

Factors influencing blood pressure control among patients with hypertension in Rwanda: the role of patients and caretakers

BMC Public Health
Background Hypertension (HTN) is a leading cause of cardiovascular diseases and premature death, disproportionately affecting low- and middle-income countries.
Liberee Kubwimana, Pascaline Uwase Nsanzurwanda, Genereuse Irakoze Iradukunda, Joyeuse Urujeni, Natnael Shimelash, Rex Wong   +5 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

On the use of receiver operating characteristic curve analysis to determine the most appropriate p value significance threshold

Journal of Translational Medicine
Background p value is the most common statistic reported in scientific research articles. Choosing the conventional threshold of 0.05 commonly used for the p value in research articles, is unfounded.
Farrokh Habibzadeh
doaj   +1 more source

A high spatial resolution dataset of China’s biomass resource potential

Scientific Data, 2023
Assessing biomass resource potential is essential for China’s ambitious goals of carbon neutrality, rural revitalization, and poverty eradication. To fill the data gap of high spatial resolution biomass resources in China, this study estimates the ...
Rui Wang, Wenjia Cai, Le Yu, Wei Li, Lei Zhu, Bowen Cao, Jin Li, Jianxiang Shen, Shihui Zhang, Yaoyu Nie, Can Wang   +10 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source