Results 81 to 90 of about 11,091,979 (254)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Electron highways

, 2018
The performance of enzymatic biofuel cells is greatly hindered by the poor electron transfer between enzyme catalysts and electrode surfaces. Now, an efficient electrical connection is made by coupling conventional direct and mediated electron transfer ...
Tang, Zhiyong, Huajie Yin, Yin, Huajie, Zhiyong Tang   +3 more
core   +1 more source

Trapped electron mode in a quasi-isodynamic stellarator

Nuclear Fusion
Global gyrokinetic simulations find a strongly unstable trapped electron mode excited by a density gradient in a quasi-isodynamic stellarator. The eigenmode structure localizes on the inner side of the torus with an unfavorable magnetic curvature and ...
Javier H. Nicolau, Xishuo Wei, Pengfei Liu, Gyungjin Choi, Zhihong Lin   +4 more
doaj   +1 more source

Hydrated Sodium Ion Clusters [Na+(H2O)n (n = 1–6)]: An ab initio Study on Structures and Non-covalent Interaction

Frontiers in Chemistry, 2019
Structural, thermodynamic, and vibrational characteristics of water clusters up to six water molecules incorporating a single sodium ion [Na+(H2O)n (n = 1–6)] are calculated using a comprehensive genetic algorithm combined with density functional theory ...
Pengju Wang, Ruili Shi, Ruili Shi, Yan Su, Lingli Tang, Xiaoming Huang, Jijun Zhao   +6 more
doaj   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Two-Electron- and One-Electron-Transfer Pathways for TEMPO-Catalyzed Greener Electrochemical Dimerization of 3‑Substituted-2-Oxindoles

, 2023
Dimerized 3-substituted 2-oxindoles are essential building blocks for the total synthesis of alkaloids. Herein, three different types of 3-substituted-2-oxindoles were dimerized with a total of 41 examples employing TEMPO as a redox mediator and TEMPO ...
Alakesh Bisai (1470907), Saina Shaheeda, Saina Shaheeda (14497998), Kundan Shaw (9591807), Amit Paul (579703), Kundan Shaw, Alakesh Bisai, Sulekha Sharma, Amit Paul, Sulekha Sharma (9591804)   +9 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Density Functional Theory Study on Electron and Hole Transport Properties of Organic Pentacene Derivatives with Electron-Withdrawing Substituent

, 2011
Density Functional Theory Study on Electron and Hole Transport Properties of Organic Pentacene Derivatives with Electron-Withdrawing SubstituentAttaching electron-withdrawing substituent to organic conjugated molecules is considered as an effective ...
Wen, Shu-Hao, Huang, Jin-Dou, Jin-Dou Huang, 韩克利, Shu-Hao Wen, Han, Ke-Li, Chai, Shuo, Ke-Li Han, Shuo Chai   +8 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Large ionospheric disturbances during a minor geomagnetic storm on June 23, 2000

Annals of Geophysics, 2012
We investigate the variations in the ionosphere during a small geomagnetic storm on June 23, 2000, using the total electron content of the Jet Propulsion Laboratory global positioning system, and the ionospheric critical frequency. Large and long-lasting
Zheng Li, Fengsi Wei, Xueshang Feng, Jianpeng Guo, Barbara A Emery, Xinhua Zhao   +5 more
doaj   +1 more source