Results 41 to 50 of about 6,210,205 (314)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Global Existence and Optimal Decay Rates of Solutions for Compressible Hall-MHD Equations [PDF]

open access: yes, 2015
In this paper, we are concerned with global existence and optimal decay rates of solutions for the three-dimensional compressible Hall-MHD equations.
Jincheng Gao, Z. Yao
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Global existence and semiclassical limit for quantum hydrodynamic equations with viscosity and heat conduction [PDF]

open access: yes, 2015
The hydrodynamic equations with quantum effects are studied in this paper. First we establish the global existence of smooth solutions with small initial data and then in the second part, we establish the convergence of the solutions of the quantum ...
Xueke Pu, B. Guo
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Global existence and boundedness in a parabolic-elliptic Keller-Segel system with general sensitivity

open access: yes, 2015
This paper is concerned with the parabolic-elliptic Keller-Segel system with signal-dependent sensitivity $\chi(v)$, \begin{align*} \begin{cases} u_t=\Delta u - \nabla \cdot ( u \nabla \chi(v)) &\mathrm{in}\ \Omega\times(0,\infty), \\ 0=\Delta ...
Kentarou Fujie, T. Senba
semanticscholar   +1 more source

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