Results 71 to 80 of about 6,210,205 (314)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Global existence for semilinear parabolic systems.

Journal für die reine und angewandte Mathematik (Crelles Journal), 1985
This paper studies the problem of global existence for strongly coupled semilinear parabolic systems of arbitrary even order under linear time- dependent boundary conditions. In particular it is shown that there exist classical global solutions provided the nonlinearity satisfies appropriate polynomial growth restrictions and a priori estimates in some
openaire   +2 more sources

Local and global existence theorems for the Einstein equations [PDF]

Living Reviews in Relativity, 1998
This article is a guide to the literature on existence theorems for the Einstein equations which also draws attention to open problems in the field. The local in time Cauchy problem, which is relatively well understood, is treated first. Next global results for solutions with symmetry are discussed.
openaire   +9 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Global Existence for an Isotropic Landau Model

SIAM Journal on Mathematical Analysis
Abstract Following the recent ideas of Guillen and Silvestre, we prove that the Fisher information is non-increasing along the flow of the isotropic Landau equation. We then use this fact to deduce global existence for the equation ∂tf = (−∆)−1f · ∆f + f2 under a relatively lax set of conditions on the initial data. In particular, we remove the
Bowman, David, Ji, Sehyun
openaire   +3 more sources

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Future global existence and stability of de Sitter-like solutions to the Einstein-Yang-Mills equations in spacetime dimensions $n\geq 4$ [PDF]

, 2022
Chao Liu, Todd A. Oliynyk, Jinhua Wang
openalex   +1 more source

Existence of a Global Solution for a Viscoelastic System

Journal of Mathematical Analysis and Applications, 1998
The author considers the Cauchy problem for the viscoelastic system \[ v_t- u_x= 0,\quad u_t- f(v)_x+ ku= u_{xx} \] without the restriction that the initial data approach constants at infinity. Existence of unique classical solution is proved, including a priori estimates.
openaire   +2 more sources