Results 21 to 30 of about 8,503 (217)

Flourishing as a Measure of Global Well-being in First Year Residents: A Pilot Longitudinal Cohort Study [PDF]

Journal of Medical Education and Curricular Development, 2021
Background: Physician well-being is critical to optimal learning and performance, yet we remain without validated measures to gauge the efficacy of well-being curricula for trainees. This study evaluates initial evidence of flourishing as a valid measure
Carter C Lebares, Anya L Greenberg, Amy Shui, Christy Boscardin, Marieke van der Schaaf   +4 more
doaj   +5 more sources

Association between psychological well-being, sleep quality, and academic performance among physical therapy students [PDF]

Frontiers in Medicine
BackgroundSleep, a core health behavior, contributes significantly to psychological well-being, whereas flourishing represents an individual’s highest level of mental functioning and emotional health.
Noha F. Mahmoud, Leena Alghamdi, Tarfa Almuaither, Riyam Alqabani, Danah Alabdulathim, Munirah Alotaibi, Afrah Almuwais, Azza M. Atya   +7 more
doaj   +2 more sources

Childhood predictors of social support and intimate friends in a Cross-National analysis of the global flourishing study. [PDF]

Sci Rep
An extensive research literature describes how close social connections (CSC) comprising both intimate friends and relatives and friends who help when in trouble are one of the most significant predictors of improved well-being outcomes, approximately equivalent to a 5-fold increase in income, in some contexts.
Ritchie-Dunham JL, Yancey G, Managi S, Bartel C, Bonhag R, Padgett RN, Shiba K, Johnson BR, VanderWeele TJ.   +8 more
europepmc   +3 more sources

Characterizing the childhood roots of adult sense of mastery across 22 countries in the global flourishing study. [PDF]

Sci Rep
Abstract How might we cultivate a life imbued with a sense of mastery? An expanding body of research demonstrates that a heightened sense of mastery improves health and well-being outcomes. Despite this, it remains unclear which childhood factors foster increased mastery in adulthood. Further, existing studies have examined this question only
Kim ES, Bradshaw M, Chen Y, Chopik WJ, Okuzono SS, Wilkinson R, Padgett RN, Lachman ME, Johnson BR, VanderWeele TJ.   +9 more
europepmc   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Global Trends of Mean and Inequality in Multidimensional Wellbeing: Analysis of 1.2 Million Individuals From 162 Countries, 2009–2019

Frontiers in Public Health, 2022
IntroductionHuman flourishing is a multidimensional concept characterized by a state of complete wellbeing. However, much of the prior research on wellbeing has principally focused on population averages assessed using a single item of wellbeing.
Koichiro Shiba, Koichiro Shiba, Richard G. Cowden, Natasha Gonzalez, Matthew T. Lee, Tim Lomas, Alden Yuanhong Lai, Tyler J. VanderWeele, Tyler J. VanderWeele, Tyler J. VanderWeele   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Understanding who volunteers globally through an examination of demographic variation in volunteering across 22 countries

Scientific Reports
Volunteering has been associated with enhanced individual and societal well-being around the world. While some prior research has assessed cultural and sociodemographic differences in volunteering, we know little about how volunteering differs across ...
Julia S. Nakamura, Cristina B. Gibson, Robert D. Woodberry, Matthew T. Lee, Young-Il Kim, Koichiro Shiba, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The roots of belonging: childhood predictors of belonging in 22 countries

Scientific Reports
Belonging is a fundamental human need, yet its origins in childhood experiences remain underexplored. Childhood predictors of belonging in adulthood using nationally representative data have also largely been overlooked. This study analyzes data from the
Victor Counted, Kelly-Ann Allen, Byron R. Johnson, Tyler J. VanderWeele   +3 more
doaj   +1 more source