Results 181 to 190 of about 5,856,508 (299)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paradigm Shift in Global Governance of Medical Brain-Computer Interface: Addressing Practical Challenges Through Institutional Innovation. [PDF]

Risk Manag Healthc Policy
Zhu R, Zhao Y, Li Y.
europepmc   +1 more source

Governing antimicrobial resistance: a narrative review of global governance mechanisms. [PDF]

J Public Health Policy, 2020
Ruckert A, Ruckert A, Fafard P, Hindmarch S, Morris A, Packer C, Patrick D, Weese S, Wilson K, Wong A, Labonté R.   +10 more
europepmc   +1 more source

WHO simulations for youth engagement in global governance in a post-COVID world: Opportunities and challenges of moving conferences online. [PDF]

J Glob Health, 2021
Li J, John A, Tasos E, Koerling AL, Rendina C, Elshaer A, Brunet C, Magdy A, Lyszkowski A, van Daalen K.   +9 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

A "True Lifecycle Approach" towards governing healthcare AI with the GCC as a global governance model. [PDF]

NPJ Digit Med
Solaiman B, Mekki YM, Qadir J, Ghaly M, Abdelkareem M, Al-Ansari A.   +5 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Rethinking the Central Role of Equity in the Global Governance of Pandemic Response. [PDF]

J Bioeth Inq, 2020
Eyawo O, Viens AM.
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Learning from the Montreal Protocol to improve the global governance of antimicrobial resistance. [PDF]

BMJ Glob Health
Nanyangwe-Moyo T, Fezza GC, Rogers Van Katwyk S, Hoffman SJ, Ruckert A, Orubu S, Poirier MJ.   +6 more
europepmc   +1 more source