Results 41 to 50 of about 254,442 (188)

Implications of nonzero $\theta_{13}$ for the neutrino mass hierarchy

, 2012
The Daya Bay, RENO, and Double Chooz experiments have discovered a large non-zero value for $\theta_{13}$. We present a global analysis that includes these three experiments, Chooz, the Super-K atmospheric data, and the $\nu_\mu \rightarrow \nu_e$ T2K ...
Burroughs, H. R., Cogswell, B. K., Ernst, D. J., Escamilla-Roa, J., Latimer, D. C.   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Caring About Value: A grounded theory of the quest to move towards higher value care in hospitals

SSM: Qualitative Research in Health
Caring About Value: A grounded theory of the quest for higher value care in hospitals.The global pursuit of ‘value’ in hospitals continues amid rising healthcare costs. Traditionally, value in this context has focused on costs and benefits.
Zephanie Tyack, Michelle J. Allen, Ian Scott, Katrina L. Campbell, Roy M. Kimble, Anne B. Chang, Steven M. McPhail   +6 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

“What Kind of Migrant Are You?”—Iranian Migrants in the West, Racial Complexity and Myths of Belonging

Genealogy
In this article, I analyse the complexity of the status of “migrant” in relation to myths of belonging and what we call “home”. I look at status labels that Iranian border-crossers embrace after migrating to the Global North and the ways in which they ...
Shima Shahbazi
doaj   +1 more source

Observables sensitive to absolute neutrino masses: Constraints and correlations from world neutrino data

, 2004
In the context of three-flavor neutrino mixing, we present a thorough study of the phenomenological constraints applicable to three observables sensitive to absolute neutrino masses: The effective neutrino mass in Tritium beta decay (m_beta); the ...
A. Marrone, A. Melchiorri, A. Palazzo, B. Pontecorvo, B. Pontecorvo, C. Cattadori, E. Lisi, F. Vissani, F. Vissani, G. L. Fogli, J. Silk, J. N. Abdurashitov, M. Doi, P. Serra, S. Hannestad, T. Kirsten, Z. Maki   +16 more
core   +1 more source